Evidence map›Paper›PMID 26536157›Full record

ArticleCancer investigation2016

Proteomic Profiling of Serum-Derived Exosomes from Ethnically Diverse Prostate Cancer Patients.

David Turay, Salma Khan, Carlos J Diaz Osterman, Matthew P Curtis, Balreet Khaira, Jonathan W Neidigh, Saied Mirshahidi, Carlos A Casiano, Nathan R Wall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David Turaya Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.
Salma Khana Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.
Carlos J Diaz Ostermana Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.
Matthew P Curtisb Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
Balreet Khairab Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
Jonathan W Neidighb Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
Saied Mirshahidic Department of Basic Science and Division of Microbiology and Molecular Genetics , Loma Linda University School of Medicine , Loma Linda , California , USA.
Carlos A Casianoa Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.
Nathan R Walla Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.

Funding

NIH-LLU Initiative for Maximizing Student DiversityR25GM060507 · NIGMS · LOMA LINDA UNIVERSITY · PI DE LEON, MARINO · 2001 to 2022
$11.3M
Research Training/Education CoreP20MD006988 · NIMHD · LOMA LINDA UNIVERSITY · PI CASIANO, CARLOS A. · 2012 to 2016
$6.2M
NIGMS NIH HHS 2R25 GM060507NIGMS NIH HHS R25 GM060507NIMHD NIH HHS P20 MD006988NIMHD NIH HHS P20MD006988
6 · The paper itself

Abstract

Prostate cancer (PCa) remains the most frequently diagnosed male malignancy in Western countries and the second most common cause of male cancer death in the United States. The relatively elevated PCa incidence and mortality among African American men makes this cancer type a challenging health disparity disease. To increase the chance for successful trea tment, earlier detection and prediction of tumor aggress iveness will be important and need to be resolved. This study demonstrates that small membrane-bound vesicles shed from the tumor called exosomes contain ethnically and tumor-specific biomarkers, and could be exploited for their diagnostic and therapeutic potential.

Indexed as

EthnicityProteomeProteomicsBiomarkers, TumorCase-Control StudiesComputational BiologyExosomesHumansMaleProstatic NeoplasmsBiomarkers, TumorProteomeBiomarkerEarly detectionExosomeHealth disparityProstate cancerProteome

Identifiers

PMID26536157
PMCPMC4732892

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.