ArticleBiochemistry2015
A Ferredoxin Disulfide Reductase Delivers Electrons to the Methanosarcina barkeri Class III Ribonucleotide Reductase.
Article in Biochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Iron-mediated C(spTetrahedron · 2025Article
- Iron-Catalyzed Cross-Electrophile Coupling.Synlett : accounts and rapid communications in synthetic organic chemistry · 2025Article
- C(spCommunications chemistry · 2025Article
- Characterization of a second class Ie ribonucleotide reductase.Communications biology · 2025Article
- Modeling the Initiation Phase of the Catalytic Cycle in the Glycyl-Radical Enzyme Benzylsuccinate Synthase.The journal of physical chemistry. B · 2024Article
- Protein engineering a PhotoRNR chimera based on a unifying evolutionary apparatus among the natural classes of ribonucleotide reductases.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cross-Electrophile Coupling of Benzyl Halides and Disulfides Catalyzed by Iron.Journal of the American Chemical Society · 2024Article
- An integrated systems biology approach reveals differences in formate metabolism in the genusiScience · 2023Article
- Article
- Structural determinants and distribution of phosphate specificity in ribonucleotide reductases.The Journal of biological chemistry · 2021Article
- A ferredoxin-dependent dihydropyrimidine dehydrogenase in Clostridium chromiireducens.Bioscience reports · 2020Article
- Analysis of RNA Methylation by Phylogenetically Diverse Cfr RadicalBiochemistry · 2019Article
- Non-host class II ribonucleotide reductase in Thermus viruses: sequence adaptation and host interaction.PeerJ · 2019Article
- Crystal Structure of the Apo-Form of NADPH-Dependent Thioredoxin Reductase from a Methane-Producing Archaeon.Antioxidants (Basel, Switzerland) · 2018Article
- Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole.Nature communications · 2018Article
- Toward a mechanistic and physiological understanding of a ferredoxin:disulfide reductase from the domains Archaea and Bacteria.The Journal of biological chemistry · 2018Article
- New tricks for the glycyl radical enzyme family.Critical reviews in biochemistry and molecular biology · 2017Review
- A unique cysteine-rich zinc finger domain present in a majority of class II ribonucleotide reductases mediates catalytic turnover.The Journal of biological chemistry · 2017Article
- A prominent glycyl radical enzyme in human gut microbiomes metabolizesScience (New York, N.Y.) · 2017Article
- Methanosarcina acetivorans utilizes a single NADPH-dependent thioredoxin system and contains additional thioredoxin homologues with distinct functions.Microbiology (Reading, England) · 2017Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Two subtypes of class III anaerobic ribonucleotide reductases (RNRs) studied so far couple the reduction of ribonucleotides to the oxidation of formate, or the oxidation of NADPH via thioredoxin and thioredoxin reductase. Certain methanogenic archaea contain a phylogenetically distinct third subtype of class III RNR, with distinct active-site residues. Here we report the cloning and recombinant expression of the Methanosarcina barkeri class III RNR and show that the electrons required for ribonucleotide reduction can be delivered by a [4Fe-4S] protein ferredoxin disulfide reductase, and a conserved thioredoxin-like protein NrdH present in the RNR operon. The diversity of class III RNRs reflects the diversity of electron carriers used in anaerobic metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.