Evidence map›Paper›PMID 26536130›Full record

ArticlePloS one2015

Aging Is Accompanied by a Blunted Muscle Protein Synthetic Response to Protein Ingestion.

Benjamin Toby Wall, Stefan H Gorissen, Bart Pennings, René Koopman, Bart B L Groen, Lex B Verdijk, Luc J C van Loon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 15 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 15 syntheses or guidelines pooled it, 331 citations in OpenAlex.

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  6. Protein Intake and Sarcopenia in Older Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Benjamin Toby WallNUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, 6200 MD, The Netherlands.
Stefan H GorissenNUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, 6200 MD, The Netherlands.
Bart PenningsNUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, 6200 MD, The Netherlands.
René KoopmanNUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, 6200 MD, The Netherlands.
Bart B L GroenNUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, 6200 MD, The Netherlands.
Lex B VerdijkNUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, 6200 MD, The Netherlands.
Luc J C van LoonNUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, 6200 MD, The Netherlands.
Maastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeProgressive loss of skeletal muscle mass with aging (sarcopenia) forms a global health concern. It has been suggested that an impaired capacity to increase muscle protein synthesis rates in response to protein intake is a key contributor to sarcopenia. We assessed whether differences in post-absorptive and/or post-prandial muscle protein synthesis rates exist between large cohorts of healthy young and older men. PROCEDURES: We performed a cross-sectional, retrospective study comparing in vivo post-absorptive muscle protein synthesis rates determined with stable isotope methodologies between 34 healthy young (22±1 y) and 72 older (75±1 y) men, and post-prandial muscle protein synthesis rates between 35 healthy young (22±1 y) and 40 older (74±1 y) men.

findingsPost-absorptive muscle protein synthesis rates did not differ significantly between the young and older group. Post-prandial muscle protein synthesis rates were 16% lower in the older subjects when compared with the young. Muscle protein synthesis rates were >3 fold more responsive to dietary protein ingestion in the young. Irrespective of age, there was a strong negative correlation between post-absorptive muscle protein synthesis rates and the increase in muscle protein synthesis rate following protein ingestion.

conclusionsAging is associated with the development of muscle anabolic inflexibility which represents a key physiological mechanism underpinning sarcopenia.

Indexed as

AgingAgedCross-Sectional StudiesDietary ProteinsHumansMaleMuscle ProteinsPostprandial PeriodProtein BiosynthesisRetrospective StudiesSarcopeniaYoung AdultDietary ProteinsMuscle Proteins

Identifiers

PMID26536130
PMCPMC4633096
OpenAlexW2169812053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.