Evidence map›Paper›PMID 26536119›Full record

Trial reportPloS one2015

Association between Dietary Magnesium Intake and Hyperuricemia.

Yi-Lun Wang, Chao Zeng, Jie Wei, Tuo Yang, Hui Li, Zhen-Han Deng, Ye Yang, Yi Zhang, Xiang Ding, Dong-Xing Xie and 2 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  7. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yi-Lun WangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Chao ZengDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Jie WeiDepartment of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, 410008, China.
Tuo YangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Hui LiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Zhen-Han DengDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Ye YangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Yi ZhangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Xiang DingDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Dong-Xing XieDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Tu-Bao YangDepartment of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, 410008, China.
Guang-Hua LeiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the cross-sectional associations between dietary magnesium (Mg) intake and hyperuricemia (HU).

methods5168 subjects were included in this study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Hyperuricemia (HU) was defined as uric acid ≥ 416 μmol/L for male population and ≥ 360 μmol/L for female. A multivariable logistic analysis model was applied to test the associations after adjusting a number of potential confounding factors.

resultsThe relative odds of the overall prevalence of HU were decreased by 0.57 times in the fourth quintile of Mg intake (OR 0.57, 95% CI 0.35-0.94) and 0.55 times in the fifth quintile (OR 0.55, 95% CI 0.30-1.01) comparing with the lowest quintile, and P for trend was 0.091. The results of multivariable linear regression also suggested a significant inverse association between serum uric acid and Mg intake (β = -0.028, P = 0.022). For male, the relative odds of HU were decreased by 0.62 times in the third quintile of Mg intake (OR 0.62, 95% CI 0.40-0.97), 0.40 times in the fourth quintile (OR 0.40, 95% CI 0.23-0.72) and 0.35 times in the fifth quintile (OR 0.35, 95% CI 0.17-0.71) comparing with the lowest quintile, and P for trend was 0.006. Multivariable adjusted inverse association was also existed between serum uric acid and Mg intake in male population (β = -0.061, P = 0.002). However, no significant association was observed between dietary Mg intake and HU for female.

conclusionsThe findings of this cross-sectional study indicated that dietary Mg intake is inversely associated with HU, independent of some major confounding factors. In addition, this association remains valid for the male subgroup, but not for the female subgroup. LEVEL OF EVIDENCE: LevelIII, cross-sectional study.

Indexed as

Dietary SupplementsSex CharacteristicsAgedCross-Sectional StudiesFemaleHumansHyperuricemiaMagnesiumMaleMiddle AgedMagnesium

Identifiers

PMID26536119
PMCPMC4633057
OpenAlexW2166314541

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.