ArticlePLoS computational biology2015
Neural Sequence Generation Using Spatiotemporal Patterns of Inhibition.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Motor neurons organize Drosophila feeding sequences via a disinhibitory cascade.Nature neuroscience · 2026Article
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- Differential behavioral engagement of inhibitory interneuron subtypes in the zebra finch brain.Neuron · 2025Article
- Neuronal activation sequences in lateral prefrontal cortex encode visuospatial working memory during virtual navigation.Nature communications · 2024Article
- Model of the HVC neural network as a song motor in zebra finch.Frontiers in computational neuroscience · 2024Article
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- A feedforward inhibitory premotor circuit for auditory-vocal interactions in zebra finches.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Stimulus-Driven and Spontaneous Dynamics in Excitatory-Inhibitory Recurrent Neural Networks for Sequence Representation.Neural computation · 2021Article
- Characteristics of sequential activity in networks with temporally asymmetric Hebbian learning.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Hidden neural states underlie canary song syntax.Nature · 2020Article
- Potential factors influencing replay across CA1 during sharp-wave ripples.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Manipulations of inhibition in cortical circuitry differentially affect spectral and temporal features of Bengalese finch song.Journal of neurophysiology · 2020Article
- Unsupervised Learning of Persistent and Sequential Activity.Frontiers in computational neuroscience · 2019Article
- Article
- Unstable neurons underlie a stable learned behavior.Nature neuroscience · 2016Article
- Model of the songbird nucleus HVC as a network of central pattern generators.Journal of neurophysiology · 2016Article
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Authors and funding
4 authors.
Funding
Abstract
Stereotyped sequences of neural activity are thought to underlie reproducible behaviors and cognitive processes ranging from memory recall to arm movement. One of the most prominent theoretical models of neural sequence generation is the synfire chain, in which pulses of synchronized spiking activity propagate robustly along a chain of cells connected by highly redundant feedforward excitation. But recent experimental observations in the avian song production pathway during song generation have shown excitatory activity interacting strongly with the firing patterns of inhibitory neurons, suggesting a process of sequence generation more complex than feedforward excitation. Here we propose a model of sequence generation inspired by these observations in which a pulse travels along a spatially recurrent excitatory chain, passing repeatedly through zones of local feedback inhibition. In this model, synchrony and robust timing are maintained not through redundant excitatory connections, but rather through the interaction between the pulse and the spatiotemporal pattern of inhibition that it creates as it circulates the network. These results suggest that spatially and temporally structured inhibition may play a key role in sequence generation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.