ArticleKidney international2016
Phenotyping by magnetic resonance imaging nondestructively measures glomerular number and volume distribution in mice with and without nephron reduction.
Article in Kidney international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 68 citations in OpenAlex.
- Are noninvasive measurements of nephron number achievable in humans?Current opinion in nephrology and hypertension · 2026Review
- Preterm Birth Increases Susceptibility to Hyperglycemia-Induced Kidney Injury With Sex-Specific Differences in Structural and Molecular Responses.Endocrinology, diabetes & metabolism · 2026Article
- Preserving nephron number in children after preterm birth: a top priority.Pediatric nephrology (Berlin, Germany) · 2026Article
- AutoGlom: software tool for segmentation and analysis of magnetic resonance images of the kidney.American journal of physiology. Renal physiology · 2026Article
- Beyond Hyperfiltration: Comprehensive Morphometric Assessment of Nephrons and Podocytes.Journal of the American Society of Nephrology : JASN · 2026Article
- Counting glomeruli in human kidney specimens using ex vivo MRI without contrast agents.Magnetic resonance in medicine · 2025Article
- Preterm birth increases susceptibility to hyperglycemia induced glomerular alterations in male mice.Scientific reports · 2025Article
- Development and Use of Human RecombinantACS applied bio materials · 2024Article
- Chronic Kidney Disease Progression-A Challenge.Biomedicines · 2024Review
- Resting-state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats.American journal of physiology. Renal physiology · 2024Article
- Mice with aAmerican journal of physiology. Renal physiology · 2024Article
- Comparison of preparation methods of rat kidney single-cell suspensions.Scientific reports · 2024Article
- Renal MRI: From Nephron to NMR Signal.Journal of magnetic resonance imaging : JMRI · 2023Review
- Article
- Use of novel structural features to identify urinary biomarkers during acute kidney injury that predict progression to chronic kidney disease.BMC nephrology · 2023Article
- A versatile vessel casting method for fine mapping of vascular networks using a hydrogel-based lipophilic dye solution.Cell reports methods · 2023Article
- Synthesis and Expression of a Targeted, Ferritin-Based Tracer for PET Imaging of Kidney Glomeruli.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Mapping single-nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging.American journal of physiology. Renal physiology · 2022Article
- Cryo-fluorescence micro-optical sectioning tomography for volumetric imaging of various whole organs with subcellular resolution.iScience · 2022Article
- Cholesterol Metabolism in Chronic Kidney Disease: Physiology, Pathologic Mechanisms, and Treatment.Advances in experimental medicine and biology · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Reduced nephron mass is strongly linked to susceptibility to chronic renal and cardiovascular diseases. There are currently no tools to identify nephropenia in clinical or preclinical diagnostics. Such new methods could uncover novel mechanisms and therapies for chronic kidney disease (CKD) and reveal how variation among traits can affect renal function and morphology. Here we used cationized ferritin (CF)–enhanced MRI (CFE-MRI) to investigate the relationship between glomerular number (Nglom) and volume (Vglom) in kidneys of healthy wild-type mice and mice with oligosyndactylism (Os/+), a model of congenital nephron reduction. Mice were injected with CF and perfused, and the resected kidneys were imaged with 7T MRI to detect CF-labeled glomeruli. CFE-MRI was used to measure the intrarenal distribution of individual glomerular volumes and revealed two major populations of glomeruli distinguished by size. Spatial mapping revealed that the largest glomeruli were located in the juxtamedullary region in both wild-type and Os/+ mice and the smallest population located in the cortex. Os/+ mice had about a 50% reduction and 35% increase of Nglom and Vglom, respectively, in both glomerular populations compared with wild type, consistent with glomerular hypertrophy in the Os/+ mice. Thus, we provide a foundation for whole-kidney, MRI-based phenotyping of mouse renal glomerular morphology and provide new potential for quantitative human renal diagnostics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.