ArticleDevelopment and psychopathology2015
Harsh parent-child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma.
Article in Development and psychopathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Indoor Environmental Factors May Modify the Response to Mouse Allergen Reduction Among Mouse-Sensitized and Exposed Children with Persistent Asthma.The journal of allergy and clinical immunology. In practice · 2021Trial
- Molecular evolution in light of regulatory-coding epistasis.EMBO reports · 2026Review
- Exploring the causal link between childhood maltreatment and asthma: a Mendelian randomization study.European journal of psychotraumatology · 2025Article
- The benefits of nurturant-involved parenting for children's internalizing symptoms and cardiometabolic health in high-risk contexts.Development and psychopathology · 2023Article
- Child maltreatment and asthma.Pediatric pulmonology · 2022Review
- Influence of Parent-Child Conflict on Psychological Distress among Chinese Adolescents: Moderating Effects of School Connectedness and Neighborhood Disorder.International journal of environmental research and public health · 2022Article
- Parent-child conflict and physical health trajectories among youth with asthma.Journal of psychosomatic research · 2021Article
- How does the social world shape health across the lifespan? Insights and new directions.The American psychologist · 2020Article
- The impact of cumulative stress on asthma outcomes among urban adolescents.Journal of adolescence · 2020Article
- Self-Disclosure and Perceived Responsiveness Among Youth With Asthma: Links to Affect and Anti-Inflammatory Gene Expression.Personality & social psychology bulletin · 2019Article
- Familism and inflammatory processes in African American, Latino, and White youth.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Article
- Assessment of genetic factor and depression interactions for asthma symptom severity in cohorts of childhood and elderly asthmatics.Experimental & molecular medicine · 2018Article
- Affective processes as mediators of links between close relationships and physical health.Social and personality psychology compass · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Asthma is a chronic respiratory disorder that affects over 7 million children in the United States. Evidence indicates that family stressors are associated with worsening of asthma symptoms, and some research suggests that these stressful experiences engender changes in children's immune systems in ways that exacerbate airway inflammation and contribute to both acute and chronic asthma symptoms. We examined the association between observed experiences of parent-child conflict and the expression of signaling molecules involved in the transduction of anti-inflammatory signals that regulate airway inflammation and obstruction. Fifty-seven children and their parents participated in a conflict task, and coders rated interactions for evidence of harsh and supportive behaviors. Children reported on their perceptions of parental support and reported on their daily asthma symptoms for 2 weeks. We collected peripheral blood in children to measure leukocyte expression of messenger RNA for the glucocorticoid receptor and the β2-adrenergic receptor. Analyses revealed that harsh conflict behaviors were associated with decreased expression of both messenger RNAs and more severe asthma symptoms. Neither supportive behaviors nor perceived parental support was associated with gene expression or asthma symptoms. These findings suggest that harsh interactions with parents are associated with downregulation of key anti-inflammatory signaling molecules and difficulties breathing in children with asthma. Children with asthma who are also victims of maltreatment may be particularly susceptible to transcriptional changes in immune cells that could worsen asthma over time.
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Registered trials
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