ArticleJournal of the American Chemical Society2015
A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
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- Ecological Prevalence and Non-Enzymatic Formation of Imidazolium Alkaloids on Moon Snail Egg Collars.Molecules (Basel, Switzerland) · 2026Article
- Antarmycins: Discovery, Biosynthesis, Anti-pathogenic Bacterial Activity, and Mechanism of Action from Deep-Sea-DerivedJACS Au · 2025Article
- Actinomycetes associated with hymenopteran insects: a promising source of bioactive natural products.Frontiers in microbiology · 2024Review
- Isolation, characterization and screening of actinomycetes associated with fijian ant-plant symbioses.Microbiology (Reading, England) · 2023Article
- Prospects of Topoisomerase Inhibitors as Promising Anti-Cancer Agents.Pharmaceuticals (Basel, Switzerland) · 2023Review
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- Genome Evolution of a Symbiont Population for Pathogen Defense in Honeybees.Genome biology and evolution · 2022Article
- Strategies to access biosynthetic novelty in bacterial genomes for drug discovery.Nature reviews. Drug discovery · 2022Review
- New Glycosylated Polyene Macrolides: Refining the Ore from Genome Mining.Antibiotics (Basel, Switzerland) · 2022Review
- Chemical Exchanges between Multilateral Symbionts.Organic letters · 2021Article
- Specialized Metabolites Reveal Evolutionary History and Geographic Dispersion of a Multilateral Symbiosis.ACS central science · 2021Article
- Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311.Bioorganic & medicinal chemistry · 2021Article
- Polyene-ProducingFrontiers in microbiology · 2021Article
- Chemical warfare between fungus-growing ants and their pathogens.Current opinion in chemical biology · 2020Review
- Review
- Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani.PLoS neglected tropical diseases · 2019Article
- Concepts and Methods to Access Novel Antibiotics from Actinomycetes.Antibiotics (Basel, Switzerland) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Bacterial symbionts of fungus-growing ants occupy a highly specialized ecological niche and face the constant existential threat of displacement by another strain of ant-adapted bacteria. As part of a systematic study of the small molecules underlying this fraternal competition, we discovered an analog of the antitumor agent rebeccamycin, a member of the increasingly important indolocarbazole family. While several gene clusters consistent with this molecule's newly reported modification had previously been identified in metagenomic studies, the metabolite itself has been cryptic. The biosynthetic gene cluster for 9-methoxyrebeccamycin is encoded on a plasmid in a manner reminiscent of plasmid-derived peptide antimicrobials that commonly mediate antagonism among closely related Gram-negative bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.