ArticlePloS one2015
Multimorbidities and Overprescription of Proton Pump Inhibitors in Older Patients.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Polypharmacy in outpatients with relapsing-remitting multiple sclerosis: A single-center study.PloS one · 2019Trial
- Dietary Prebiotics Modulate Omeprazole-Induced Alterations in the Gut Microbial Signature.Molecular nutrition & food research · 2025Article
- Insights into stress ulcer prophylaxis among non-critically ill patients: a tertiary hospital perspective from Sudan.Journal of pharmaceutical health care and sciences · 2025Article
- Proton pump inhibitors and cardiovascular risk: a critical review.Future cardiology · 2024Review
- Deprescribing of proton pump inhibitors in older patients: A cost-effectiveness analysis.PloS one · 2024Article
- Clinical Factors Implicated in Antibiotic Resistance inMicroorganisms · 2022Review
- Review
- Characterization of potentially inappropriate medication prescriptions for the elderly in primary care and hospital settings.Journal of family medicine and primary care · 2021Article
- The inappropriate use of proton pump inhibitors and its associated factors among community-dwelling older adults.Heliyon · 2021Article
- Medication-related factors associated with proton pump inhibitor prescription beyond official guidelines in older adults.European geriatric medicine · 2020Article
- Patient Awareness of Reported Adverse Effects Associated with Proton Pump Inhibitors in a Medically Underserved Community.Healthcare (Basel, Switzerland) · 2020Article
- Proton pump inhibitors and the risk of hospital-acquired acute kidney injury in children.Annals of translational medicine · 2020Article
- Potentially Inappropriate Drug Prescribing in French Nursing Home Residents: An Observational Study.Pharmacy (Basel, Switzerland) · 2020Article
- Pharmaceutical intervention in the rational use of intravenous omeprazole.Einstein (Sao Paulo, Brazil) · 2020Article
- Multi-drug use among patients with multiple sclerosis: A cross-sectional study of associations to clinicodemographic factors.Scientific reports · 2019Article
- Nutritional Considerations of Cardiovascular Diseases and Treatments.Nutrition and metabolic insights · 2019Review
- A cross-sectional study of national outpatient gastric acid suppressant prescribing in the United States between 2009 and 2015.PloS one · 2018Article
- Drug-Induced Kidney Injury in the Elderly.Drugs & aging · 2017Review
- Acid-Suppressive Therapy and Risk of Infections: Pros and Cons.Clinical drug investigation · 2017Review
- Optimization of drug therapy in elderly individuals admitted to a geriatric unit.Clinical interventions in aging · 2017Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine whether there is an association between overprescription of proton pump inhibitors (PPIs) and multimorbidities in older patients.
designMulticenter prospective study.
settingAcute geriatric medicine at the University Hospital of Nantes and the Hospital of Saint-Nazaire.
participantsOlder patients aged 75 and over hospitalized in acute geriatric medicine. MEASUREMENTS: Older patients in acute geriatric medicine who received proton pump inhibitors. Variables studied were individual multimorbidities, the burden of multimorbidity evaluated by the Cumulative Illness Rating Scale, age, sex, type of residence (living in nursing home or not), functional abilities (Lawton and Katz scales), nutritional status (Body Mass Index), and the type of concomitant medications (antiaggregant, corticosteroids', or anticoagulants).
resultsOverprescription of proton pump inhibitors was found in 73.9% older patients. In the full model, cardiac diseases (odds ratio [OR] = 4.17, p = 0.010), metabolic diseases (OR = 2.14, p = 0.042) and corticosteroids (OR = 5.39, p = 0.028) were significantly associated with overprescription of proton pump inhibitors. Esogastric diseases (OR = 0.49, p = 0.033) were negatively associated with overprescription of proton pump inhibitors.
conclusionCardiac diseases and metabolic diseases were significantly associated with overprescription of proton pump inhibitors.
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