ArticlePloS one2015
(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis through Increasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Antiphotoaging properties ofToxicological research · 2022Article
- Phytochemicals and Bioactivities ofMolecules (Basel, Switzerland) · 2021Review
- Indonesian Ginger (Bangle) Extract Promotes Neurogenesis of Human Neural Stem Cells through WNT Pathway Activation.International journal of molecular sciences · 2020Article
- Src inhibition induces melanogenesis in human G361 cells.Molecular medicine reports · 2019Article
- Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMP kinase activation.British journal of pharmacology · 2019Article
- Safety Assessment of Bangle (ACS omega · 2018Article
- Treatment Strategies for Hypopigmentation in the Context of Burn Hypertrophic Scars.Plastic and reconstructive surgery. Global open · 2018Article
- Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids.Evidence-based complementary and alternative medicine : eCAM · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the potential melanogenic effect of compounds from Zingiber cassumunar Roxb. Our data revealed that chloroform-soluble extract of Z. cassumunar enhanced melanin synthesis in B16F10 melanoma cells. Among the components of the chloroform extract, (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol (DMPB) increased melanogenesis in both B16F10 cells and human primary melanocytes. In B16F10 cells, DMPB enhanced the activation of ERK and p38, and the level of tyrosinase. Although the level of microphthalmia-associated transcription factor was unchanged in DMPB-treated B16F10 cells, DMPB increased levels and nuclear localization of upstream stimulating factor-1 (USF1). Consistently, DMPB-mediated melanin synthesis was diminished in USF1-knockdown cells. Furthermore, DMPB induced hyperpigmentation in brown guinea pigs in vivo. Together, these data suggest that DMPB may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypopigmentation-associated diseases.
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