ArticleCPT: pharmacometrics & systems pharmacology2015
Physiome-on-a-Chip: The Challenge of "Scaling" in Design, Operation, and Translation of Microphysiological Systems.
Article in CPT: pharmacometrics & systems pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Cancer-on-a-chip for precision cancer medicine.Lab on a chip · 2025Review
- A 3D-printed multi-compartment organ-on-chip platform with a tubing-free pump models communication with the lymph node.Lab on a chip · 2025Article
- Liver-on-chips for drug discovery and development.Materials today. Bio · 2024Review
- Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research.PLoS computational biology · 2022Article
- Engineering Modular 3D Liver Culture MicroenvironmentsAdvanced nanobiomed research · 2022Article
- Patient-Specific Organoid and Organ-on-a-Chip: 3D Cell-Culture Meets 3D Printing and Numerical Simulation.Advanced biology · 2021Review
- Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology.Micromachines · 2021Review
- Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips.Nature biomedical engineering · 2020Article
- Strategies for using mathematical modeling approaches to design and interpret multi-organ microphysiological systems (MPS).APL bioengineering · 2019Review
- Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System.CPT: pharmacometrics & systems pharmacology · 2019Article
- Integrated Microphysiological Systems: Transferable Organ Models and Recirculating Flow.Advanced biosystems · 2019Review
- Perspective: The promise of multi-cellular engineered living systems.APL bioengineering · 2018Article
- Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips.Journal of visualized experiments : JoVE · 2018Article
- Maximizing the impact of microphysiological systems with in vitro-in vivo translation.Lab on a chip · 2018Article
- Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies.Scientific reports · 2018Article
- Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies.Scientific reports · 2018Article
- Traction force microscopy of engineered cardiac tissues.PloS one · 2018Article
- Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk.Biotechnology and bioengineering · 2017Article
- Tissue chips - innovative tools for drug development and disease modeling.Lab on a chip · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation. This dual approach reduces the need to perfectly rescale and mimic in vivo physiology, an aspiration that is both extremely challenging and not substantively meaningful because of uncertain relevance of any specific physiological condition. Accordingly, this perspective offers a tractable approach for designing interacting MPSs and relating in vitro results to analogous context in vivo.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.