Evidence map›Paper›PMID 26535137›Full record

ArticleRMD open2015

Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis.

Karine Louati, Céline Vidal, Francis Berenbaum, Jérémie Sellam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RMD open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 185 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed, 8 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

185 citing papers in PubMed, 8 syntheses or guidelines pooled it, 354 citations in OpenAlex.

  1. Pooled it
  2. Association of type 2 diabetes and osteoarthritis: an umbrella review of systematic reviews and meta-analyses.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025
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  20. Osteoarthritis among individuals with diabetes mellitus in Saudi Arabia.Journal of family medicine and primary care · 2026
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125 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Karine LouatiDepartment of Rheumatology , Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Antoine Hospital , Paris , France ; Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris , France ; Sorbonne Universités, UPMC Univ Paris 06 , Paris , France.
Céline VidalDepartment of Rheumatology , Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Antoine Hospital , Paris , France ; Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris , France.
Francis BerenbaumDepartment of Rheumatology , Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Antoine Hospital , Paris , France ; Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris , France ; Sorbonne Universités, UPMC Univ Paris 06 , Paris , France ; Faculté de Médecine Saint Antoine , INSERM UMR_S 938 , Paris , France.
Jérémie SellamDepartment of Rheumatology , Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Antoine Hospital , Paris , France ; Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris , France ; Sorbonne Universités, UPMC Univ Paris 06 , Paris , France ; Faculté de Médecine Saint Antoine , INSERM UMR_S 938 , Paris , France.
Assistance Publique – Hôpitaux de Paris · FRCentre de Recherche Saint-Antoine · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the prevalence of osteoarthritis (OA) in patients with diabetes mellitus (DM) and prevalence of DM in patients with OA and whether OA and DM are associated.

designA systematic literature review and meta-analysis. We included cohort, case-control and cross-sectional studies assessing the number of patients with DM and/or OA. The mean prevalence of OA among patients with DM and DM among patients with OA was calculated. Data from trials assessing an association of diabetes and OA were pooled and results are presented as unadjusted OR and 95% CI.

resultsFrom the 299 publications, we included 49 studies in the analysis, including 28 cross-sectional studies, 11 cohort studies and 10 case-control studies. In all, 21, 5 and 23 articles involved patients with OA exclusively, patients with DM and the general population, respectively. For 5788 patients with DM, the mean OA prevalence was 29.5±1.2%. For 645 089 patients with OA, the prevalence of DM was 14.4±0.1%. The risk of OA was greater in the DM than non-DM population (OR=1.46 (1.08 to 1.96), p=0.01), as was DM in the OA than non-OA population (OR=1.41 (1.21 to 1.65), p<0.00 001). Among the 12 studies reporting an OR adjusted on at least the body mass index, 5 showed no association of DM and OA and 7 identified DM as an independent risk factor.

conclusionsThis meta-analysis highlights a high frequency of OA in patients with DM and an association between both diseases, representing a further step towards the individualisation of DM-related OA within a metabolic OA phenotype.

Indexed as

EpidemiologyHand OsteoarthritisOsteoarthritis

Identifiers

PMID26535137
PMCPMC4613158
OpenAlexW2126243764

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.