ReviewUnited European gastroenterology journal2015
The genetic epidemiology of diverticulosis and diverticular disease: Emerging evidence.
Review in United European gastroenterology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Pooled it
- Genetic, epigenetic and environmental factors in diverticular disease: systematic review.BJS open · 2024Pooled it
- Pooled it
- The Epidemiology of Diverticulitis.Clinics in colon and rectal surgery · 2025Review
- Diverticulitis: A Review of Current and Emerging Practice-Changing Evidence.Clinics in colon and rectal surgery · 2024Review
- Quantification and significance of extraprostatic findings on prostate MRI: a retrospective analysis and three-tier classification.Insights into imaging · 2023Article
- Genetic Variants in Matrix MetalloproteinasesMedicina (Kaunas, Lithuania) · 2023Article
- 150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility.Cell genomics · 2023Article
- Article
- Right-sided diverticulitis in a Western population.International journal of colorectal disease · 2022Article
- Dose-dependent reduction of lymphocyte count and heart rate after multiple administration of LC51-0255, a novel sphingosine-1-phosphate receptor 1 modulator, in healthy subjects.Frontiers in pharmacology · 2022Article
- Challenging Surgical Dogma: Controversies in Diverticulitis.The Surgical clinics of North America · 2021Review
- The Epidemiology and Etiology of Right-Sided Colonic Diverticulosis: A Review.Annals of coloproctology · 2021Review
- Evaluation of molecular and genetic predisposing parameters at diverticular disease of the colon.International journal of colorectal disease · 2021Review
- Colonic Diverticulosis. Is there a Genetic Component?Maedica · 2020Article
- Etiopathogenetic Mechanisms in Diverticular Disease of the Colon.Cellular and molecular gastroenterology and hepatology · 2020Review
- Diverticular disease epidemiology: acute hospitalisations are growing fastest in young men.Techniques in coloproctology · 2019Article
- Genome-wide association study of right-sided colonic diverticulosis in a Korean population.Scientific reports · 2019Article
- Maternal Uniparental Disomy 14 (UPD14) Identified by Clinical Exome Sequencing in an Adolescent with Diverticulosis.ACG case reports journal · 2019Article
- Risk of colorectal cancer in patients with diverticular disease.World journal of clinical oncology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diverticular disease (DD) is one of the most prevalent gastrointestinal disorders. The pathogenesis of diverticulosis and DD is controversially discussed. Current studies call the traditional concept of a fibre-deficient diet causing the development of diverticula into question. Data from two recent twin studies have provided conclusive evidence for a strong genetic component to diverticulosis. Although genomewide association studies have provided new insights into the polygenic architecture of human diseases, genomic research in diverticulosis and DD has just been started. This is an astonishing fact given the high morbidity and mortality of the disease, as well as the substantial economic burden on health care systems. For this review, we provide an update of the molecular pathobiology and summarise recent evidence supporting the hypothesis that distinct, yet unidentified genetic variants contribute to the development of diverticulosis and DD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.