ArticleDevelopment (Cambridge, England)2015
EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex.
Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
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- Excess cerebellar granule neurons induced by the absence of p75NTR during development elicit social behavior deficits in mice.Frontiers in molecular neuroscience · 2023Article
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- Early postnatal gene expression in the developing neocortex of prairie voles (Microtus ochrogaster) is related to parental rearing style.The Journal of comparative neurology · 2020Article
- Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder.Neuropsychiatric disease and treatment · 2020Article
- miRNA-mRNA Associated With Survival in Endometrial Cancer.Frontiers in genetics · 2019Article
- PlexinA1 is crucial for the midline crossing of callosal axons during corpus callosum development in BALB/cAJ mice.PloS one · 2019Article
- Homeogene emx1 is required for nephron distal segment development in zebrafish.Scientific reports · 2018Article
- NFIB Haploinsufficiency Is Associated with Intellectual Disability and Macrocephaly.American journal of human genetics · 2018Article
- Prenatal Alcohol Exposure Is Associated With Adverse Cognitive Effects and Distinct Whole-Genome DNA Methylation Patterns in Primary School Children.Frontiers in behavioral neuroscience · 2018Article
- Emx1 Is Required for Neocortical Area Patterning.PloS one · 2016Article
- Deciphering the Role ofFrontiers in molecular neuroscience · 2016Article
- Combined allelic dosage ofBrain and neuroscience advancesArticle
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 4 countries.
Funding
Abstract
Transcription factors act during cortical development as master regulatory genes that specify cortical arealization and cellular identities. Although numerous transcription factors have been identified as being crucial for cortical development, little is known about their downstream targets and how they mediate the emergence of specific neuronal connections via selective axon guidance. The EMX transcription factors are essential for early patterning of the cerebral cortex, but whether EMX1 mediates interhemispheric connectivity by controlling corpus callosum formation remains unclear. Here, we demonstrate that in mice on the C57Bl/6 background EMX1 plays an essential role in the midline crossing of an axonal subpopulation of the corpus callosum derived from the anterior cingulate cortex. In the absence of EMX1, cingulate axons display reduced expression of the axon guidance receptor NRP1 and form aberrant axonal bundles within the rostral corpus callosum. EMX1 also functions as a transcriptional activator of Nrp1 expression in vitro, and overexpression of this protein in Emx1 knockout mice rescues the midline-crossing phenotype. These findings reveal a novel role for the EMX1 transcription factor in establishing cortical connectivity by regulating the interhemispheric wiring of a subpopulation of neurons within the mouse anterior cingulate cortex.
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