ArticleBritish journal of clinical pharmacology2016
Creatinine-based equations for the adjustment of drug dosage in an obese population.
Article in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Long-term kidney outcomes of semaglutide in obesity and cardiovascular disease in the SELECT trial.Nature medicine · 2024Trial
- Clinical factors associated with biased estimation of glomerular filtration rate: a cross-sectional study.Clinical kidney journal · 2026Article
- Impact of GFR on Mortality Risk After Biliopancreatic Diversion: Challenges and Pitfalls for the Clinician.Obesity surgery · 2025Article
- De-indexed estimated glomerular filtration rates for the dosing of oral antidiabetic drugs in patients with chronic kidney disease.Frontiers in pharmacology · 2024Article
- Adjustment of creatinine clearance for carboplatin dosing in Calvert's formula and clinical efficacy for lung cancer.Cancer medicine · 2023Observational
- Estimation of Glomerular Filtration Rate in Obese Patients: Utility of a New Equation.Nutrients · 2023Article
- Comparison of creatinine-based equations for estimating renal function for digoxin dose adjustment in patients with atrial fibrillation and heart failure.Pharmacology research & perspectives · 2023Article
- Estimation of glomerular filtration rate for drug dosing in patients with very high or low body mass index.Clinical and translational science · 2022Article
- Development and assessment of PharmaCheck: an electronic screening tool for the prevention of twenty major adverse drug events.BMC medical informatics and decision making · 2022Article
- Development of a decision flowchart to identify the patients need high-dose vancomycin in early phase of treatment.Journal of pharmaceutical health care and sciences · 2022Article
- Article
- Accuracy of freely available online GFR calculators using the CKD-EPI equation.European journal of clinical pharmacology · 2020Article
- An Adjusted Ideal Body Weight Index Formula With Fresh Frozen Plasma (FFP) Rescue Decreases Fluid Creep During Burn Resuscitation.Annals of burns and fire disasters · 2020Article
- The estimation of GFR and the adjustment for BSA in overweight and obesity: a dreadful combination of two errors.International journal of obesity (2005) · 2020Article
- How to adjust drug doses in chronic kidney disease.Australian prescriber · 2019Review
- Unexpected excessive apixaban exposure: case report of a patient with polymorphisms of multiple apixaban elimination pathways.BMC pharmacology & toxicology · 2019Article
- Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study.Pharmaceutical research · 2019Observational
- Improvement of renal function estimation equations for elderly Japanese people.Health science reports · 2018Article
- Methods of Estimating Kidney Function for Drug Dosing in Special Populations.Clinical pharmacokinetics · 2018Review
- Influence of the recipient body mass index on the outcomes after kidney transplantation.Langenbeck's archives of surgery · 2018Article
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimFor drug dosing adaptation, the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend using estimated glomerular filtration rate (eGFR) by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, after 'de-indexation' by body surface area (BSA). In pharmacology, the Cockcroft-Gault (CG) equation is still recommended to adapt drug dosage. In the context of obesity, adjusted ideal body weight (AIBW) is sometimes preferred to actual body weight (ABW) for the CG equation. The aim of the present study was to compare the performance of the different GFR-estimating equations, non-indexed or de-indexed by BSA for the purpose of drug-dosage adaptation in obese patients.
methodsWe analysed data from patients with a body mass index (BMI) higher than 30 kg m(-2) who underwent a GFR measurement. eGFR was calculated using the CKD-EPI and Modification of Diet in Renal Disease (MDRD) equations, de-indexed by BSA, and the CG equation, using either ABW, AIBW or lean body weight (LBW) for the weight variable and compared with measured GFR, expressed in ml min(-1).
resultsIn our population of obese patients, use of the AIBW instead of the ABW in the CG equation, markedly improved the overall accuracy of this equation [57% for CGABW and 79% for CGAIBW (P < 0.05)]. For high BMI (over 40 kg m(-2)), the accuracy of the CG equations is no different when using LBW than when using AIBW. The MDRD and CKD-EPI equations de-indexed by the BSA also performed well, with an overall higher accuracy for the MDRD de-indexed equation [(80% and 76%, respectively (P < 0.05)].
conclusionsThe de-indexed MDRD equation appeared to be the most suitable for estimating the non-indexed GFR for the purpose of drug dosage adaptation in obese patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.