Evidence map›Paper›PMID 26531802›Full record

ArticleJournal of exposure science & environmental epidemiology2016

Contribution of breast milk and formula to arsenic exposure during the first year of life in a US prospective cohort.

Courtney C Carignan, Margaret R Karagas, Tracy Punshon, Diane Gilbert-Diamond, Kathryn L Cottingham

Open access · greenAbstract read
In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  3. Frontiers in epidemiology · 2023
    Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Courtney C CarignanChildren's Environmental Health and Disease Prevention Research Center at Dartmouth, Hanover, NH, USA.
Margaret R KaragasChildren's Environmental Health and Disease Prevention Research Center at Dartmouth, Hanover, NH, USA.
Tracy PunshonChildren's Environmental Health and Disease Prevention Research Center at Dartmouth, Hanover, NH, USA.
Diane Gilbert-DiamondChildren's Environmental Health and Disease Prevention Research Center at Dartmouth, Hanover, NH, USA.
Kathryn L CottinghamChildren's Environmental Health and Disease Prevention Research Center at Dartmouth, Hanover, NH, USA.
Dartmouth College · USHarvard University · US

Funding

Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI CHRISTENSEN, BROCK CLARKE · 2013 to 2022
$23.7M
Project 3: Placental Biomarkers of Exposure and Outcome (Marsit)P01ES022832 · NIEHS · DARTMOUTH COLLEGE · PI MURRAY, CAROLYN J · 2013 to 2018
$4.7M
Project 4: Determining How Arsenic Modulates Hedgehog Signaling During DevelopmenP20ES018175 · NIEHS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 2010 to 2012
$892k
NIEHS NIH HHS P01 ES022832NIEHS NIH HHS P20 ES018175NIGMS NIH HHS P20 GM104416
6 · The paper itself

Abstract

Arsenic is a carcinogen that can also affect the cardiac, respiratory, neurological and immune systems. Children have higher dietary arsenic exposure than adults owing to their more restricted diets and greater intake per unit body mass. We evaluated the potential contributions of breast milk and formula to arsenic exposure throughout the first year of life for 356 infants in the prospective New Hampshire Birth Cohort Study (NHBCS) using infant diets reported by telephone at 4, 8 and 12 months of age; measured household water arsenic concentrations; and literature data. Based on our central-tendency models, population-wide geometric mean (GM) estimated arsenic exposures in the NHBCS were relatively low, decreasing from 0.1 μg/kg/day at 4 months of age to 0.07 μg/kg/day at 12 months of age. At all three time points, exclusively formula-fed infants had GM arsenic exposures ~8 times higher than exclusively breastfed infants owing to arsenic in both tap water and formula powder. Estimated maximum exposures reached 9 μg/kg/day among exclusively formula-fed infants in households with high tap water arsenic (80 μg/l). Overall, modeled arsenic exposures via breast milk and formula were low throughout the first year of life, unless formula was prepared with arsenic-contaminated tap water.

Indexed as

AdolescentAdultArsenicBreast FeedingDrinkingDrinking WaterFemaleHumansInfantInfant FormulaInfant, NewbornMaleMiddle AgedMilk, HumanNew HampshireProspective StudiesArsenicDrinking WaterWater Pollutants, Chemical

Identifiers

PMID26531802
PMCPMC4854790
OpenAlexW1949863778

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.