Evidence map›Paper›PMID 26531695›Full record

ArticleJournal of neuroimmunology2015

Social disruption alters pain and cognition in an animal model of multiple sclerosis.

H R Linsenbardt, J L Cook, E E Young, E G Vichaya, C R Young, N M Reusser, R Storts, C J Welsh, M W Meagher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

H R LinsenbardtDepartment of Psychology, Texas A&M University, College Station, TX, United States; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, United States.
J L CookDepartment of Psychology, Texas A&M University, College Station, TX, United States.
E E YoungDepartment of Psychology, Texas A&M University, College Station, TX, United States.
E G VichayaDepartment of Psychology, Texas A&M University, College Station, TX, United States.
C R YoungDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United States.
N M ReusserDepartment of Psychology, Texas A&M University, College Station, TX, United States.
R StortsDepartment of Veterinary Pathobiology, Texas A&M University, College Station, TX, United States.
C J WelshTexas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, United States; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United States.
M W MeagherDepartment of Psychology, Texas A&M University, College Station, TX, United States; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, United States. Electronic address: m-meagher@tamu.edu.
Texas A&M University · US

Funding

Impact of social stress-induced cytokines on an animal model of MSR01NS060822 · NINDS · TEXAS A&M UNIVERSITY · PI MEAGHER, MARY W. · 2008 to 2011
$999k
NINDS NIH HHS R01 NS060822NINDS NIH HHS R01-NS060822
6 · The paper itself

Abstract

Although pain and cognitive deficits are widespread and debilitating symptoms of multiple sclerosis (MS), they remain poorly understood. Theiler's murine encephalomyelitis virus (TMEV) infection is an animal model of MS where disease course is exacerbated by prior stressors. Here chronic infection coupled with prior social stress increased pain behavior and impaired hippocampal-dependent memory consolidation during the demyelinating phase of disease in SJL mice. These results suggest that the TMEV model may be useful in investigating pain and cognitive impairments in MS. However, in contrast to prior Balb/cJ studies, stress failed to consistently alter behavioral and physiological indicators of disease course.

Indexed as

AnimalsBehavior, AnimalCardiovirus InfectionsCognitionDisease Models, AnimalMaleMiceMultiple SclerosisPainStress, PsychologicalTheilovirusCognitionMultiple sclerosisPainPavlovian conditioningSocial stressTheiler's murine encephalomyelitis virus

Identifiers

PMID26531695
PMCPMC4633706
OpenAlexW1832468931

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.