Evidence map›Paper›PMID 26531065›Full record

ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2015

Tissue Xpert™ MTB/Rif assay is of limited use in diagnosing peritoneal tuberculosis in patients with exudative ascites.

Chinmay Bera, Joy Sarojini Michael, Deepak Burad, Suzana B Shirly, Sridhar Gibikote, Banumathi Ramakrishna, Ashish Goel, C E Eapen

Abstract readEvaluation Study
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In one paragraph

Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. XpertThe Cochrane database of systematic reviews · 2018
    Pooled it
  4. Article
  5. Article
  6. Article
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  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Chinmay BeraDepartment of Hepatology, Christian Medical College, Vellore, 632 004, India.
Joy Sarojini MichaelDepartment of Microbiology, Christian Medical College, Vellore, 632 004, India.
Deepak BuradDepartment of Pathology, Christian Medical College, Vellore, 632 004, India.
Suzana B ShirlyDepartment of Microbiology, Christian Medical College, Vellore, 632 004, India.
Sridhar GibikoteDepartment of Radiology, Christian Medical College, Vellore, 632 004, India.
Banumathi RamakrishnaDepartment of Pathology, Christian Medical College, Vellore, 632 004, India.
Ashish GoelDepartment of Hepatology, Christian Medical College, Vellore, 632 004, India. drashishgoel@cmcvellore.ac.in.
C E EapenDepartment of Hepatology, Christian Medical College, Vellore, 632 004, India.
Christian Medical College & Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundXpert™ MTB/Rif is a multiplex hemi-nested real-time PCR-based assay to detect presence of M. tuberculosis within 2 hours of sample collection. The present study aimed at assessing efficacy of Xpert™ MTB/Rif assay for diagnosing peritoneal tuberculosis.

methodsPatients with exudative ascites, fluid negative for acid-fast bacilli on auramine O fluorescence staining and unyielding fluid cytology for malignant cells, were included. Ultrasound-guided omental biopsy samples were obtained in all. Xpert™ MTB/Rif assay on tissue samples was assessed against a composite "reference" standard for diagnosis of peritoneal tuberculosis, defined as presence of any of the three-culture showing M tuberculosis, granulomatous inflammation on histology or resolution of ascites with 2 months of antitubercular therapy.

resultsDuring January 2012-July 2013, 28 patients (age:43 ± 15 years; mean ± SD; male:20) were recruited. Serum ascitic albumin gradient was <1.1 in all except in four patients with underlying cirrhosis. Twenty-one of the 28 patients had peritoneal TB as diagnosed by composite reference standard (histology:18; culture:4; treatment response:3). Seven patients (25%) had an alternative diagnosis (metastatic carcinoma 2, adenocarcinoma 2, mesothelioma 2, and systemic lupus erythematous 1). Xpert™ MTB/Rif assay was positive in 4/21 patients with peritoneal tuberculosis and in none of the 7 patients with alternative diagnosis. Thus, sensitivity, specificity, positive, and negative predictive values for tissue Xpert™ MTB/Rif assay in diagnosing peritoneal tuberculosis were 19% (95% C.I: 6% to 42%), 100% (95% C.I: 59% to 100%), 100% (40% to 100%), and 29% (95% C.I: 13% to 51%), respectively. INTERPRETATION AND

conclusionTissue Xpert™ MTB/Rif assay was of limited use in diagnosing peritoneal tuberculosis.

Indexed as

AdultAscitesExudates and TransudatesFemaleHumansMaleMiddle AgedMycobacterium tuberculosisOmentumPeritonitis, TuberculousReal-Time Polymerase Chain ReactionSensitivity and SpecificityTime FactorsGranulomaM. tuberculosisOmental biopsyXpert™ MTB/Rif assay

Identifiers

PMID26531065
OpenAlexW2245595014

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.