Trial reportObesity (Silver Spring, Md.)2015
Effects of carbohydrate quantity and glycemic index on resting metabolic rate and body composition during weight loss.
Trial report in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of carbohydrate-restricted diets and macronutrient replacements on cardiovascular health and body composition in adults: a meta-analysis of randomized trials.The American journal of clinical nutrition · 2025Pooled it
- Pooled it
- Low glycaemic index diets for the prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2017Pooled it
- The Effect of a Low-Energy and Low-Glycemic Diet on Adipose Tissue Metabolism and Energy Expenditure in Women with Excess Body Weight.Nutrients · 2025Trial
- Trial
- Adaptive thermogenesis after moderate weight loss: magnitude and methodological issues.European journal of nutrition · 2022Trial
- Substituting whole grains for refined grains in a 6-wk randomized trial favorably affects energy-balance metrics in healthy men and postmenopausal women.The American journal of clinical nutrition · 2017Trial
- Estimating the reliability of glycemic index values and potential sources of methodological and biological variability.The American journal of clinical nutrition · 2016Trial
- Effects of the Paleo diet on resting metabolic rate in handball players.Scientific reports · 2026Article
- Metabolic adaptation following gastric bypass surgery: results from a 2-year observational study.International journal of obesity (2005) · 2024Observational
- The Effect of High Protein-High Fat and High Protein-High Carbohydrate Meals on Resting Metabolic Rate and Metabolic Factors in Overweight and Obese Adults: The Study Protocol for a Randomized Crossover Clinical Trial.International journal of endocrinology and metabolism · 2024Article
- Obesity and malnutrition in children and adults: A clinical review.Obesity pillars · 2023Review
- Low glycaemic index or low glycaemic load diets for people with overweight or obesity.The Cochrane database of systematic reviews · 2023Review
- Position statement on nutrition therapy for overweight and obesity: nutrition department of the Brazilian association for the study of obesity and metabolic syndrome (ABESO-2022).Diabetology & metabolic syndrome · 2023Review
- The BREAK study protocol: Effects of intermittent energy restriction on adaptive thermogenesis during weight loss and its maintenance.PloS one · 2023Article
- The energy balance model of obesity: beyond calories in, calories out.The American journal of clinical nutrition · 2022Review
- The association of Carbohydrate Quality Index with cardiovascular disease risk factors among women with overweight and obesity: A cross-sectional study.Frontiers in nutrition · 2022Article
- Is there any putative mediatory role of inflammatory markers on the association between ultra-processed foods and resting metabolic rate?Frontiers in nutrition · 2022Article
- The low-carbohydrate-diet score is associated with resting metabolic rate: an epidemiologic study among Iranian adults.Journal of diabetes and metabolic disorders · 2021Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveTo examine the effects of diets varying in carbohydrate and glycemic index (GI) on changes in body composition, resting metabolic rate (RMR), and metabolic adaptation during and after weight loss.
methodsAdults with obesity (n = 91) were randomized to one of four provided-food diets for 17 weeks. Diets differed in percentage energy from carbohydrate (55% or 70%) and GI (low or high) but were matched for protein, fiber, and energy. Body weight, body composition, RMR, and metabolic adaptation (measured RMR-predicted RMR) were measured during weight loss and subsequent weight stability.
resultsNo effect of dietary carbohydrate content or GI on body weight loss or percentage of weight lost as fat mass (FM) was observed. Measured RMR was significantly lower (-226 kJ/day [95% CI: -314 to -138 kJ/day], P < 0.001) than predicted RMR following weight loss, but this difference was attenuated after 5 weeks of weight stability. Metabolic adaptation did not differ by dietary carbohydrate content or GI and was not associated with weight regain 12 months later.
conclusionsModerate-carbohydrate and low-GI diets did not preferentially reduce FM, preserve lean mass, or attenuate metabolic adaptation during weight loss compared to high-carbohydrate and high-GI diets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.