Observational studyJournal of clinical hypertension (Greenwich, Conn.)2016
Association Between Adiposity and Left Ventricular Mass in Children With Hypertension.
Observational study in Journal of clinical hypertension (Greenwich, Conn.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Prevalence of left ventricular hypertrophy in children and young people with primary hypertension: Meta-analysis and meta-regression.Frontiers in cardiovascular medicine · 2022Pooled it
- Prevalence of Overweight and Obesity in Pediatric Congenital Heart Disease: Associations with Hypertension and Echocardiographic Findings.Children (Basel, Switzerland) · 2026Article
- Aldosterone and Cardiovascular Risk Across the Lifespan.Metabolites · 2025Review
- Prevalence and impact of abnormal blood pressure on left ventricular hypertrophy in adolescents with congenital heart disease.American journal of preventive cardiology · 2025Article
- Left Ventricular Diastolic Dysfunction Among Youth with Obesity and History of Elevated Blood Pressure.The Journal of pediatrics · 2021Article
- Impact of Pediatric Obesity on Diurnal Blood Pressure Assessment and Cardiovascular Risk Markers.Frontiers in pediatrics · 2021Article
- Neutrophil to Lymphocyte Ratio Is Increased and Associated With Left Ventricular Diastolic Function in Newly Diagnosed Essential Hypertension Children.Frontiers in pediatrics · 2021Article
- Clinical Decision Support for the Diagnosis and Management of Adult and Pediatric Hypertension.Current hypertension reports · 2020Review
- Adiposity, Sex, and Cardiovascular Disease Risk in Children With CKD: A Longitudinal Study of Youth Enrolled in the Chronic Kidney Disease in Children (CKiD) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2020Observational
- Subclinical Organ Damage in Children and Adolescents with Hypertension: Current Guidelines and Beyond.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019Review
- Predictors and Consequences of Pediatric Hypertension: Have Advanced Echocardiography and Vascular Testing Arrived?Current hypertension reports · 2019Review
- Real-World Strategies to Treat Hypertension Associated with Pediatric Obesity.Current hypertension reports · 2019Review
- Association of mood disorders with cardiovascular disease risk factors in overweight and obese youth with elevated blood pressure.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Evaluation and Management of Stage 2 Hypertension in Pediatric Patients.Current hypertension reports · 2018Review
- Prevalence of Target Organ Damage in Chinese Hypertensive Children and Adolescents.Frontiers in pediatrics · 2018Article
- Ambulatory systolic blood pressure and obesity are independently associated with left ventricular hypertrophic remodeling in children.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017Article
- Obesity-Related Hypertension in Children.Frontiers in pediatrics · 2017Review
- Association Between Adiposity and Left Ventricular Mass in Children With Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Observational
- The Role of Obesity in the Development of Left Ventricular Hypertrophy Among Children and Adolescents.Current hypertension reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Left ventricular hypertrophy (LVH) is prevalent among hypertensive children; however, blood pressure (BP) does not predict its presence. The authors conducted a 1-year prospective cohort study to examine the hypothesis that obesity-related risk factors are associated with left ventricular mass index (LVMI) in hypertensive children, and the association between adiposity and LVMI is mediated by BP-dependent and -independent pathways. A total of 49 hypertensive children were enrolled: 51% were overweight/obese and 41% had LVH at baseline. Children overweight/obese at baseline and follow-up had a greater LVMI increase than those of healthy weight at each visit: mean change of 6.4 g/m(2.7) vs 0.95 g/m(2.7) . Baseline body mass index z score was independently associated with LVMI change (β=4.08, 1.54-6.61; P=.002). Only pulse pressure and serum aldosterone partially mediated this relationship. Hypertensive youth manifest multiple cardiovascular disease risk factors that worsen over time despite treatment. Of these, adiposity is most associated with LVH and increasing LVMI.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.