ArticleScientific reports2015
Adaptation of the autotrophic acetogen Sporomusa ovata to methanol accelerates the conversion of CO2 to organic products.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 114 citations in OpenAlex.
- Article
- Multi-omics analysis reveals the genetic basis for rapid COmSystems · 2025Article
- Harnessing acetogenic bacteria for one-carbon valorization toward sustainable chemical production.RSC chemical biology · 2024Review
- Adaptive laboratory evolution of Clostridium autoethanogenum to metabolize COMicrobial biotechnology · 2024Article
- Genetic tools for the electrotrophApplied and environmental microbiology · 2024Article
- Reduction, evolutionary pattern and positive selection of genes encoding formate dehydrogenase in Wood-Ljungdahl pathway of gastrointestinal acetogens suggests their adaptation to formate-rich habitats.Environmental microbiology reports · 2023Article
- Leveraging substrate flexibility and product selectivity of acetogens in two-stage systems for chemical production.Microbial biotechnology · 2023Review
- Increasing lysine level improved methanol assimilation toward butyric acid production in Butyribacterium methylotrophicum.Biotechnology for biofuels and bioproducts · 2023Article
- Genomic potential and physiological characteristics of C1 metabolism in novel acetogenic bacteria.Frontiers in microbiology · 2023Article
- Genome Sequence ofMicroorganisms · 2022Article
- Photosynthetic biohybrid coculture for tandem and tunable COProceedings of the National Academy of Sciences of the United States of America · 2022Article
- A comparative analysis of biopolymer production by microbial and bioelectrochemical technologies.RSC advances · 2022Review
- Review
- Engineering Acetogenic Bacteria for Efficient One-Carbon Utilization.Frontiers in microbiology · 2022Review
- The Potential of Sequential Fermentations in Converting C1 Substrates to Higher-Value Products.Frontiers in microbiology · 2022Review
- Metabolic changes of the acetogenFrontiers in microbiology · 2022Article
- Molecular insights and future frontiers in cell photosensitization for solar-driven COiScience · 2021Review
- Synthetic Biology on Acetogenic Bacteria for Highly Efficient Conversion of C1 Gases to Biochemicals.International journal of molecular sciences · 2020Review
- The hidden chemolithoautotrophic metabolism of Geobacter sulfurreducens uncovered by adaptation to formate.The ISME journal · 2020Article
- Electrophysiology of the Facultative Autotrophic BacteriumFrontiers in bioengineering and biotechnology · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetogens are efficient microbial catalysts for bioprocesses converting C1 compounds into organic products. Here, an adaptive laboratory evolution approach was implemented to adapt Sporomusa ovata for faster autotrophic metabolism and CO2 conversion to organic chemicals. S. ovata was first adapted to grow quicker autotrophically with methanol, a toxic C1 compound, as the sole substrate. Better growth on different concentrations of methanol and with H2-CO2 indicated the adapted strain had a more efficient autotrophic metabolism and a higher tolerance to solvent. The growth rate on methanol was increased 5-fold. Furthermore, acetate production rate from CO2 with an electrode serving as the electron donor was increased 6.5-fold confirming that the acceleration of the autotrophic metabolism of the adapted strain is independent of the electron donor provided. Whole-genome sequencing, transcriptomic, and biochemical studies revealed that the molecular mechanisms responsible for the novel characteristics of the adapted strain were associated with the methanol oxidation pathway and the Wood-Ljungdahl pathway of acetogens along with biosynthetic pathways, cell wall components, and protein chaperones. The results demonstrate that an efficient strategy to increase rates of CO2 conversion in bioprocesses like microbial electrosynthesis is to evolve the microbial catalyst by adaptive laboratory evolution to optimize its autotrophic metabolism.
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