Evidence map›Paper›PMID 26530260›Full record

ReviewJournal of neuro-oncology2015

The role of emerging therapy in the management of patients with diffuse low grade glioma.

Andrew E Sloan, Hideho Okada, Timothy C Ryken, Steven N Kalkanis, Jeffrey J Olson

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neuro-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Guideline
  2. Guidelines in the management of CNS tumors.Journal of neuro-oncology · 2021
    Guideline
  3. Review
  4. Diffuse low-grade glioma: a review on the new molecular classification, natural history and current management strategies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Andrew E SloanDepartment of Neurosurgery and Seidman Cancer Center, University Hospitals and Case Comprehensive Cancer Center, 11100 Euclid Avenue, Cleveland, OH, USA. andrew.sloan@uhhospitals.org.
Hideho OkadaUniversity of Pittsburgh, Pittsburgh, PA, USA.
Timothy C RykenDepartment of Neurosurgery, Kansas University Medical Center, Kansas City, KS, USA.
Steven N KalkanisDepartment of Neurosurgery, Henry Ford Health System, Detroit, MI, USA.
Jeffrey J OlsonDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.
Case Western Reserve University · USEmory University · USHenry Ford Health System · USUniversity Medical Center · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

questionWhat is the role of immunotherapy/tumor vaccines in the treatment of low grade gliomas? TARGET POPULATION: Adult patients with newly diagnosed WHO grade 2 astrocytoma, oligo-astroctyoma, or oligodendroglioma. RECOMMENDATIONS: There is no evidence to support a recommendation in regards to the efficacy of immunotherapy or tumor vaccines for the treatment of low grade gliomas. It is recommended that patients be enrolled in properly designed clinical trials to assess immunotherapies and tumor vaccines for low grade gliomas. QUESTION: What is the role of nutrition in the treatment of low grade gliomas? TARGET POPULATION: Adult patients with newly diagnosed WHO grade 2 astrocytoma, oligo-astroctyoma, or oligodendroglioma. RECOMMENDATIONS: There was no evidence to support a recommendation in regard to the efficacy of nutritional therapy for the treatment of low grade gliomas. It is recommended that patients be enrolled in properly designed clinical trials to assess the efficacy of nutrition for this target population. QUESTION: Is there a role for alternative or targeted therapies in the treatment of low grade gliomas? TARGET POPULATION: Adult patients with newly diagnosed WHO grade 2 astrocytoma, oligo-astroctyoma, or oligodendroglioma. RECOMMENDATION: There was no evidence to support a recommendation in regard to the efficacy of targeted or alternative agents for the treatment of low grade gliomas. It is recommended that patients be enrolled in properly designed clinical trials to assess alternative and targeted therapies for this target population.

Indexed as

Brain NeoplasmsComplementary TherapiesDietDisease ManagementGliomaHumansNeoplasm GradingAlternative therapiesAnti-angiogenic therapyImmunotherapyLow grade gliomaMolecularly targeted therapyNutrition

Identifiers

PMID26530260
OpenAlexW1958901087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.