ArticleMucosal immunology2016
Oral tolerance is inefficient in neonatal mice due to a physiological vitamin A deficiency.
Article in Mucosal immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 73 citations in OpenAlex.
- High-Dose Neonatal Vitamin A Supplementation to Bangladeshi Infants Increases the Percentage of CCR9-Positive Treg Cells in Infants with Lower Birthweight in Early Infancy, and Decreases Plasma sCD14 Concentration and the Prevalence of Vitamin A Deficiency at Two Years of Age.The Journal of nutrition · 2020Trial
- Allergens in Atopic Dermatitis.Clinical reviews in allergy & immunology · 2025Review
- Vitamin A deficiency triggers colonic methylation potentially impairing colonic neuron via downregulation SGK1/FOXO pathway.Pediatric discovery · 2024Article
- Oral tolerance to dietary antigens and Foxp3Immunological reviews · 2024Review
- Intestinal factors promoting the development of RORγtFrontiers in immunology · 2023Review
- Cutting Edge: The Expression of Transcription Inhibitor GFI1 Is Induced by Retinoic Acid to Rein in Th9 Polarization.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Breastfeeding and Allergy Effect Modified by Genetic, Environmental, Dietary, and Immunological Factors.Nutrients · 2022Review
- Lack of iron, zinc, and vitamins as a contributor to the etiology of atopic diseases.Frontiers in nutrition · 2022Review
- Allergic diseases in infancy II-oral tolerance and its failure.The World Allergy Organization journal · 2021Review
- The relationship between umbilical cord blood vitamin A levels and late preterm infant morbidities: a prospective cohort study.European journal of pediatrics · 2021Article
- The Gut‒Breast Axis: Programming Health for Life.Nutrients · 2021Review
- Oral tolerance as antigen-specific immunotherapy.Immunotherapy advances · 2021Review
- Human Milk Drives the Intimate Interplay Between Gut Immunity and Adipose Tissue for Healthy Growth.Frontiers in immunology · 2021Review
- Neonatal gut microbiome and immunity.Current opinion in microbiology · 2020Review
- Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization.Science immunology · 2020Article
- Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020Article
- Review
- Prevention of Allergy to a Major Cow's Milk Allergen by Breastfeeding in Mice Depends on Maternal Immune Status and Oral Exposure During Lactation.Frontiers in immunology · 2020Article
- Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut.Developmental cell · 2019Article
- Immunomodulatory effects of breast milk on food allergy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Review
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased risk of allergy during early life indicates deficient immune regulation in this period of life. To date, the cause for inefficient neonatal immune regulation has never been elucidated. We aimed to define the ontogeny of oral tolerance and to identify necessary conditions specific for this stage of life. Ovalbumin (OVA) was administered orally to mice through breast milk and efficiency of systemic tolerance to OVA was assessed in adulthood using a model of allergic airway inflammation. Oral tolerance induction was fully efficient starting third week of life. Inefficiency in neonates was a consequence of abnormal antigen transfer across the gut barrier and retinaldehyde dehydrogenase expression by mesenteric lymph node CD103(+) neonatal dendritic cells, resulting in inefficient T-cell activation. Neonates' serum retinol levels were three times lower than in adult mice, and vitamin A supplementation was sufficient to rescue neonatal defects and allow tolerance induction from birth. The establishment of oral tolerance required the differentiation of Th1 lymphocytes in both vitamin A-supplemented neonates and 3-week-old unsupplemented mice. This knowledge should guide the design of interventions for allergy prevention that are adapted to the neonatal stage of life such as vitamin A supplementation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.