ArticleToxicology and applied pharmacology2015
Arsenic induces structural and compositional colonic microbiome change and promotes host nitrogen and amino acid metabolism.
Article in Toxicology and applied pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 89 citations in OpenAlex.
- The gut-brain axis in arsenic-induced toxicity: mechanisms, consequences, and therapeutic perspectives.Metabolic brain disease · 2026Review
- Heavy-metal Pollution Affects Daphnia Fitness by Altering Diversity of the Gut Microbiota.Microbial ecology · 2025Article
- The influence of endocrine disruptors on the gut microbiota.Turkish journal of medical sciences · 2025Review
- Toxic metals impact gut microbiota and metabolic risk in five African-origin populations.Gut microbes reports · 2025Article
- Diverse mechanisms by which chemical pollutant exposure alters gut microbiota metabolism and inflammation.Environment international · 2024Review
- Regenerative rehabilitation measures to restore tissue function after arsenic exposure.Current opinion in biomedical engineering · 2024Article
- Arsenic Exposure-Related Hypertension in Bangladesh and Reduced Circulating Nitric Oxide Bioavailability.Environmental health perspectives · 2024Article
- The role of neighborhood deprivation in the cervicovaginal microbiota.American journal of obstetrics & gynecology MFM · 2024Article
- The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development.Cancers · 2024Review
- Toxic and essential metals: metabolic interactions with the gut microbiota and health implications.Frontiers in nutrition · 2024Review
- Influence of heavy metal exposure on gut microbiota: Recent advances.Journal of biochemical and molecular toxicology · 2023Review
- Cobalt-induced neuro-behavioural alterations are accompanied by profound Purkinje cell and gut-associated responses in rats.Environmental analysis, health and toxicology · 2023Article
- Article
- Route of Arsenic Exposure Differentially Impacts the Expression of Genes Involved in Gut-Mucosa-Associated Immune Responses and Gastrointestinal Permeability.International journal of molecular sciences · 2023Article
- Analysis of gut bacteriome ofFrontiers in microbiology · 2023Article
- Impact of Heavy Metal Toxicity on the Gut Microbiota and Its Relationship with Metabolites and Future Probiotics Strategy: a Review.Biological trace element research · 2022Review
- Air Pollution, Oxidative Stress, and the Risk of Development of Type 1 Diabetes.Antioxidants (Basel, Switzerland) · 2022Review
- Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae.World journal of microbiology & biotechnology · 2022Article
- Impact of Environmental Pollutants on Gut Microbiome and Mental Health via the Gut-Brain Axis.Microorganisms · 2022Review
- Potential Application of Living Microorganisms in the Detoxification of Heavy Metals.Foods (Basel, Switzerland) · 2022Review
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Chronic exposure to arsenic in drinking water causes cancer and non-cancer diseases. However, mechanisms for chronic arsenic-induced pathogenesis, especially in response to lower exposure levels, are unclear. In addition, the importance of health impacts from xeniobiotic-promoted microbiome changes is just being realized and effects of arsenic on the microbiome with relation to disease promotion are unknown. To investigate impact of arsenic exposure on both microbiome and host metabolism, the stucture and composition of colonic microbiota, their metabolic phenotype, and host tissue and plasma metabolite levels were compared in mice exposed for 2, 5, or 10weeks to 0, 10 (low) or 250 (high) ppb arsenite (As(III)). Genotyping of colonic bacteria revealed time and arsenic concentration dependent shifts in community composition, particularly the Bacteroidetes and Firmicutes, relative to those seen in the time-matched controls. Arsenic-induced erosion of bacterial biofilms adjacent to the mucosal lining and changes in the diversity and abundance of morphologically distinct species indicated changes in microbial community structure. Bacterical spores increased in abundance and intracellular inclusions decreased with high dose arsenic. Interestingly, expression of arsenate reductase (arsA) and the As(III) exporter arsB, remained unchanged, while the dissimilatory nitrite reductase (nrfA) gene expression increased. In keeping with the change in nitrogen metabolism, colonic and liver nitrite and nitrate levels and ratios changed with time. In addition, there was a concomitant increase in pathogenic arginine metabolites in the mouse circulation. These data suggest that arsenic exposure impacts the microbiome and microbiome/host nitrogen metabolism to support disease enhancing pathogenic phenotypes.
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