SynthesisPloS one2015
A Systematic Review and Meta-Analysis of Ilizarov Methods in the Treatment of Infected Nonunion of Tibia and Femur.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 7 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Distraction osteogenesis versus induced membrane technique for infected tibial non-unions with segmental bone loss: a systematic review of the literature and meta-analysis of available studies.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Pooled it
- Docking site interventions following bone transport using external fixation: a systematic review of the literature.International orthopaedics · 2024Pooled it
- Ilizarov method and its combined methods in the treatment of long bone defects of the lower extremity: systematic review and meta-analysis.BMC musculoskeletal disorders · 2023Pooled it
- A Systematic Review and Meta-Analysis of Combined Antibiotic Spacer with Ilizarov Methods in the Treatment of Infected Nonunion of Tibia.BioMed research international · 2021Pooled it
- Infection-free rates and Sequelae predict factors in bone transportation for infected tibia: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2018Pooled it
- Polyurethane meniscal scaffolds lead to better clinical outcomes but worse articular cartilage status and greater absolute meniscal extrusion.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Pooled it
- Incidence and Extent of Graft Extrusion following Meniscus Allograft Transplantation.BioMed research international · 2018Pooled it
- Cumulative operative burden is associated with poorer function after segmental bone transport for lower-extremity long-bone defects.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Overlapping bone transport as a bone-preserving docking strategy for a massive wedge-shaped infected tibial defect: a case report highlighting a selected reconstructive strategy.Journal of medical case reports · 2026Article
- Article
- Comparative outcomes of Adam Frame and Ilizarov external fixator in pediatric lower limb deformity correction.Journal of orthopaedic surgery and research · 2026Article
- Ilizarov Method for the Management of Infected Nonunion of the Femur With or Without Bony Defects.Cureus · 2026Article
- Internal fixation through posterolateral approach versus Ilizarov external fixation for treatment of aseptic distal tibia nonunion: a comparative analysis.Musculoskeletal surgery · 2026Article
- Strategic considerations in the treatment of infected nonunion in the lower extremity: a narrative review.International journal of surgery (London, England) · 2026Article
- Rewriting the Treatment Paradigm: Ilizarov Method Achieves High Success in Septic Non-Unions Without Local Antibiotics or Biologic Adjuncts.Biomedicines · 2025Article
- The Use of Ossein-Hydroxyapatite Complex in Conjunction with the Ilizarov Method in the Treatment of Tibial Nonunion.Journal of clinical medicine · 2025Article
- Effectiveness of the Ilizarov method in treating complex nonunions of the lower limb long bones.The Journal of international medical research · 2025Article
- Comparing Patient Communication Event Demand for External Ring Fixators to Other Common Foot and Ankle Orthopaedic Procedures: A Retrospective Study.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024Article
- Reconstruction of large post-traumatic segmental femoral defects using vascularised bone flaps: a retrospective case series.BMC musculoskeletal disorders · 2024Article
- Integrating 3D-printed customized guides with hemicorticotomy bone transport: clinical outcomes in chronic osteomyelitis management.BMC musculoskeletal disorders · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfected nonunion of tibia and femur are common in clinical practice, however, the treatment of these diseases has still been a challenge for orthopaedic surgeons. Ilizarov methods can eradicate infection, compensate bone defects and promote the bone union through progressive bone histogenesis. The objective of this systematic review was to review current available studies reporting on Ilizarov methods in the treatment of infected nonunion of tibia and femur, and to perform meta-analysis of bone and functional results and complications to evaluate the efficacy of Ilizarov methods.
methodsA comprehensive literature search was performed from the SCI, PubMed, Cochrane Library; and Embase between January 1995 and August 2015. Some major data were statistically analyzed using weighted means based on the sample size in each study by SPSS 13.0, including number of patients, mean age, mean previous surgical procedures, mean bone defects, mean length of follow-up, bone union, complications per patient, external fixation time, and external fixation index(EFI). Bone results (excellent, good, fair and poor rate), functional results (excellent, good, fair and poor rate) and complications were analyzed by Stata 9.0.
findingsA total of 590 patients from 24 studies were included in this systematic review. The average of bone union rate was 97.26% in all included studies. The poor rate in bone results and functional results was 8% (95%CI, 0.04-0.12; I2 = 44.1%, P = 0.065) and 10% (95%CI, 0.05-0.14; I2 = 34.7%, P = 0.121) in patients with infected nonunion of tibia and femur treated by Ilizarov methods. The rate of refracture, malunion, infectious recurrence, knee stiffness, amputation, limb edema and peroneal nerve palsy was respectively 4%, 7%, 5%, 12%, 4%, 13% and 13%.
conclusionsOur systematic review showed that the patients with infected nonunion of tibia and femur treated by Ilizarov methods had a low rate of poor bone and functional results. Therefore, Ilizarov methods may be a good choice for the treatment of infected nonunion of tibia and femur.
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