ArticleThe Journal of clinical investigation2015
Evidence against hypothalamic-pituitary-adrenal axis suppression in the antidiabetic action of leptin.
Article in The Journal of clinical investigation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 40 citations in OpenAlex.
- Hepatic translational rewiring in insulin deficiency identifies Reg3α as an insulin-independent glucoregulatory factor.Endocrinology · 2026Article
- Cardiometabolic regulation by adipocyte-derived leptin and the brain melanocortin system.Clinical science (London, England : 1979) · 2026Review
- Versatile smart hydrogels for spatiotemporal drug delivery to orchestrate diabetic bone regeneration.Bioactive materials · 2026Article
- Systemic Glucose Homeostasis Requires Pancreatic but Not Neuronal ATP-sensitive Potassium Channels.Function (Oxford, England) · 2025Article
- Central nervous system regulation of organismal energy and glucose homeostasis.Nature metabolism · 2021Review
- A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia.Nature communications · 2021Article
- Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism.Endocrine reviews · 2021Review
- Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin.The Journal of clinical investigation · 2020Article
- CNS Regulation of Glucose Homeostasis: Role of the Leptin-Melanocortin System.Current diabetes reports · 2020Review
- UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia.American journal of physiology. Endocrinology and metabolism · 2020Article
- Leptin Receptors in RIP-CreFrontiers in endocrinology · 2020Article
- Recent advances in understanding the role of leptin in energy homeostasis.F1000Research · 2020Review
- S100A9 extends lifespan in insulin deficiency.Nature communications · 2019Article
- Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues.Scientific reports · 2019Article
- Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases.Nature reviews. Endocrinology · 2019Review
- The circulating metabolome of human starvation.JCI insight · 2018Observational
- The Role of Leptin in Maintaining Plasma Glucose During Starvation.Postdoc journal : a journal of postdoctoral research and postdoctoral affairs · 2018Article
- Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation.Cell · 2018Article
- Leptin revisited: The role of leptin in starvation.Molecular & cellular oncology · 2018Article
- FGF1 - a new weapon to control type 2 diabetes mellitus.Nature reviews. Endocrinology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Leptin administration restores euglycemia in rodents with severe insulin-deficient diabetes, and recent studies to explain this phenomenon have focused on the ability of leptin to normalize excessive hypothalamic-pituitary-adrenal (HPA) axis activity. Here, we employed a streptozotocin-induced rat model (STZ-DM) of uncontrolled insulin-deficient diabetes mellitus (uDM) to investigate the contribution of HPA axis suppression to leptin-mediated glucose lowering. Specifically, we asked if HPA axis activation is required for diabetic hyperglycemia, whether HPA axis normalization can be achieved using a dose of leptin below that needed to normalize glycemia, and if the ability of leptin to lower plasma glucocorticoid levels is required for its antidiabetic action. In STZ-DM rats, neither adrenalectomy-induced (ADX-induced) glucocorticoid deficiency nor pharmacological glucocorticoid receptor blockade lowered elevated blood glucose levels. Although elevated plasma levels of corticosterone were normalized by i.v. leptin infusion at a dose that raises low plasma levels into the physiological range, diabetic hyperglycemia was not altered. Lastly, the potent glucose-lowering effect of continuous intracerebroventricular leptin infusion was not impacted by systemic administration of corticosterone at a dose that maintained elevated plasma levels characteristic of STZ-DM. We conclude that, although restoring low plasma leptin levels into the physiological range effectively normalizes increased HPA axis activity in rats with uDM, this effect is neither necessary nor sufficient to explain leptin's antidiabetic action.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.