ArticleThe British journal of radiology2016
T1ρ relaxation time in brain regions increases with ageing: an experimental MRI observation in rats.
Article in The British journal of radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- TNMR in biomedicine · 2026Article
- Effects of hypertension and aging on brain function in spontaneously hypertensive rats: a longitudinal resting-state functional magnetic resonance imaging study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Correction of errors in estimates of TNMR in biomedicine · 2023Article
- Comparison of TThe Journal of neuropsychiatry and clinical neurosciences · 2020Article
- T1ρ magnetic resonance: basic physics principles and applications in knee and intervertebral disc imaging.Quantitative imaging in medicine and surgery · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveT1ρ variation is associated with neurodegenerative diseases. This study aims to observe T1ρ relaxation time changes in rat brains associated with normal ageing in Sprague-Dawley (SD) rats, Wistar Kyoto (WKY) rats and spontaneously hypertension rats (SHRs).
methods18 male SD rats, 11 male WKY rats and 11 male SHRs were used. T1ρ measurement was performed at 3-T MR with a spin-lock frequency of 500 Hz. SD rats were scanned at the ages of 5, 8, 10 and 15 months. SHRs and WKY rats were scanned at the ages of 6, 9 and 12 months.
resultsFor SD rats, T1ρ at the thalamus, hippocampus and frontal cortices increased significantly from 5 to 15 months (p < 0.05). For the WKY rats and SHRs, the T1ρ values in the thalamus, hippocampus and frontal cortices also increased significantly from 6 to 12 months (p < 0.05). Furthermore, T1ρ in the thalamus, hippocampus and frontal cortices of SHRs were consistently higher than those of WKY rats at the ages of 6, 9 and 12 months (p < 0.05). The percentage regional T1ρ differences between WKY rats and SHRs did not change during ageing.
conclusionAn increase in T1ρ was associated with age-related changes of the rat brain. ADVANCES IN KNOWLEDGE: An age-related and hypertension-related T1ρ increase in rat brain regions was observed in the thalamus, hippocampus and frontal cortical regions of the rat brain.
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