ArticlePloS one2015
Computational Characterization of Exogenous MicroRNAs that Can Be Transferred into Human Circulation.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 71 citations in OpenAlex.
- DeepMiRBP: a hybrid model for predicting microRNA-protein interactions based on transfer learning and cosine similarity.BMC bioinformatics · 2024Article
- Gestational age at birth influences protein and RNA content in human milk extracellular vesicles.Journal of extracellular biology · 2024Article
- A New Frontier in Phytotherapy: Harnessing the Therapeutic Power of Medicinal Herb-derived miRNAs.Current pharmaceutical design · 2024Review
- Exploring the putative microRNAs cross-kingdom transfer inFrontiers in plant science · 2024Article
- Article
- Review
- Milk exosomes in nutrition and drug delivery.American journal of physiology. Cell physiology · 2022Review
- Extracellular vesicles enclosed-miR-421 suppresses air pollution (PMJournal of extracellular vesicles · 2022Article
- Retraction: Computational Characterization of Exogenous MicroRNAs that Can Be Transferred into Human Circulation.PloS one · 2022Article
- Exosomes provide unappreciated carrier effects that assist transfers of their miRNAs to targeted cells; I. They are 'The Elephant in the Room'.RNA biology · 2021Review
- Identification of Bovine miRNAs with the Potential to Affect Human Gene Expression.Frontiers in genetics · 2021Article
- Research on Transboundary Regulation of Plant-Derived Exogenous MiRNA Based on Biological Big Data.Journal of healthcare engineering · 2021Article
- Circulating microRNA trafficking and regulation: computational principles and practice.Briefings in bioinformatics · 2020Review
- Article
- Dietary Depletion of Milk Exosomes and Their MicroRNA Cargos Elicits a Depletion of miR-200a-3p and Elevated Intestinal Inflammation and Chemokine (C-X-C Motif) Ligand 9 Expression inCurrent developments in nutrition · 2019Article
- Dietary bovine milk exosomes elicit changes in bacterial communities in C57BL/6 mice.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Dietary microRNA-A Novel Functional Component of Food.Advances in nutrition (Bethesda, Md.) · 2019Review
- A Bioinformatics Approach to Explore MicroRNAs as Tools to Bridge Pathways Between Plants and Animals. Is DNA Damage Response (DDR) a Potential Target Process?Frontiers in plant science · 2019Article
- Concentrations of Purine Metabolites Are Elevated in Fluids from Adults and Infants and in Livers from Mice Fed Diets Depleted of Bovine Milk Exosomes and their RNA Cargos.The Journal of nutrition · 2018Article
- Olea europaea small RNA with functional homology to human miR34a in cross-kingdom interaction of anti-tumoral response.Scientific reports · 2018Article
Corrections and comments
- Retraction · 2022-05-09Breach of Policy by Author · Concerns/Issues about Data · Error in Methods · Investigation by Journal/Publisher · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
MicroRNAs have been long considered synthesized endogenously until very recent discoveries showing that human can absorb dietary microRNAs from animal and plant origins while the mechanism remains unknown. Compelling evidences of microRNAs from rice, milk, and honeysuckle transported to human blood and tissues have created a high volume of interests in the fundamental questions that which and how exogenous microRNAs can be transferred into human circulation and possibly exert functions in humans. Here we present an integrated genomics and computational analysis to study the potential deciding features of transportable microRNAs. Specifically, we analyzed all publicly available microRNAs, a total of 34,612 from 194 species, with 1,102 features derived from the microRNA sequence and structure. Through in-depth bioinformatics analysis, 8 groups of discriminative features have been used to characterize human circulating microRNAs and infer the likelihood that a microRNA will get transferred into human circulation. For example, 345 dietary microRNAs have been predicted as highly transportable candidates where 117 of them have identical sequences with their homologs in human and 73 are known to be associated with exosomes. Through a milk feeding experiment, we have validated 9 cow-milk microRNAs in human plasma using microRNA-sequencing analysis, including the top ranked microRNAs such as bta-miR-487b, miR-181b, and miR-421. The implications in health-related processes have been illustrated in the functional analysis. This work demonstrates the data-driven computational analysis is highly promising to study novel molecular characteristics of transportable microRNAs while bypassing the complex mechanistic details.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.