Evidence map›Paper›PMID 26528762›Full record

ArticleBipolar disorders2015

Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder.

Malik Nassan, Paul E Croarkin, Joan L Luby, Marin Veldic, Paramjit T Joshi, Susan L McElroy, Robert M Post, John T Walkup, Kelly Cercy, Jennifer R Geske and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bipolar disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 12 institutions in 3 countries.

Malik NassanDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Paul E CroarkinDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Joan L LubyDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Marin VeldicDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Paramjit T JoshiDepartment of Psychiatry and Behavioral Sciences, Children's National Medical Center, Washington, DC, USA.
Susan L McElroyLinder Center of HOPE, Mason, OH, USA.
Robert M PostBipolar Collaborative Network, Bethesda, MD, USA.
John T WalkupDepartment of Psychiatry, Weil Cornell Medical College, New York, NY, USA.
Kelly CercyDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Jennifer R GeskeDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Karen D WagnerDepartment of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX, USA.
Alfredo B Cuellar-BarbozaUniversidad Autonoma de Nuevo Leon, Neuvo Leon, Mexico.
Leah CasutoLinder Center of HOPE, Mason, OH, USA.
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Peter S JensenThe REACH Institute, New York, NY, USA.
Joanna M BiernackaDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic · USKarolinska Institutet · SELindner Center of HOPE · USChildren's National · USCollaborative Group (United States) · USCornell University · USMayo Clinic in Arizona · USRealistic Education in Action Coalition to Foster Health · USThe University of Texas Medical Branch at Galveston · USUniversidad Autónoma de Nuevo León · MXWashington University in St. Louis · USWinnMed · US

Funding

Treatment of Early Age Mania (TEAM)U01MH064846 · NIMH · WASHINGTON UNIVERSITY · PI GELLER, BARBARA · 2002 to 2008
$4.8M
Treatment of Early Age Mania StudyU01MH064869 · NIMH · JOHNS HOPKINS UNIVERSITY · PI RIDDLE, MARK A · 2002 to 2008
$3.3M
Treatment of Early-Age ManiaU01MH064851 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AXELSON, DAVID A · 2002 to 2008
$2.7M
Treatment of Early Age ManiaU01MH064850 · NIMH · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI WAGNER, KAREN D · 2002 to 2008
$2.7M
Treatment of Early Age Mania (TEAM)U01MH064887 · NIMH · CHILDREN'S RESEARCH INSTITUTE · PI JOSHI, PARAMJIT T. · 2002 to 2008
$2.6M
The Mayo Clinic Center for Individualized Treatment of Alcohol DependenceP20AA017830 · NIAAA · MAYO CLINIC ROCHESTER · PI CHOI, DOO-SUP · 2009 to 2010
$2.5M
Treatment of Early Age Mania (TEAM)U01MH064868 · NIMH · WASHINGTON UNIVERSITY · PI LUBY, JOAN L. · 2002 to 2008
$2.4M
METHODOLOGIES FOR TREATMENT STRATEGIESR01MH051481 · NIMH · STANFORD UNIVERSITY · PI LAVORI, PHILIP WILLIAM · 1995 to 2014
$2.3M
1H-MR Spectroscopy of Bipolar Depression Before and After Lamotrigine TreatmentR01MH079261 · NIMH · MAYO CLINIC ROCHESTER · PI FRYE, MARK A · 2009 to 2013
$1.2M
Treatment of Early Age Mania (TEAM)U01MH064911 · NIMH · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI EMSLIE, GRAHAM J. · 2002 to 2003
$777k
Glutamate Probes in Adolescent DepressionK23MH100266 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2014 to 2017
$685k
NIAAA NIH HHS P20 AA017830NIMH NIH HHS K23 MH100266NIMH NIH HHS R01 MH051481NIMH NIH HHS R01 MH079261NIMH NIH HHS U01 MH064846NIMH NIH HHS U01 MH064850NIMH NIH HHS U01 MH064851NIMH NIH HHS U01 MH064868NIMH NIH HHS U01 MH064869NIMH NIH HHS U01 MH064887NIMH NIH HHS U01 MH064911
6 · The paper itself

Abstract

objectivesBrain-derived neurotrophic factor (BDNF) Val66Met (rs6265) functional polymorphism has been implicated in early-onset bipolar disorder. However, results of studies are inconsistent. We aimed to further explore this association.

methodsDNA samples from the Treatment of Early Age Mania (TEAM) and Mayo Clinic Bipolar Disorder Biobank were investigated for association of rs6265 with early-onset bipolar disorder. Bipolar cases were classified as early onset if the first manic or depressive episode occurred at age ≤19 years (versus adult-onset cases at age >19 years). After quality control, 69 TEAM early-onset bipolar disorder cases, 725 Mayo Clinic bipolar disorder cases (including 189 early-onset cases), and 764 controls were included in the analysis of association, assessed with logistic regression assuming log-additive allele effects.

resultsComparison of TEAM cases with controls suggested association of early-onset bipolar disorder with the rs6265 minor allele [odds ratio (OR) = 1.55, p = 0.04]. Although comparison of early-onset adult bipolar disorder cases from the Mayo Clinic versus controls was not statistically significant, the OR estimate indicated the same direction of effect (OR = 1.21, p = 0.19). When the early-onset TEAM and Mayo Clinic early-onset adult groups were combined and compared with the control group, the association of the minor allele rs6265 was statistically significant (OR = 1.30, p = 0.04).

conclusionsThese preliminary analyses of a relatively small sample with early-onset bipolar disorder are suggestive that functional variation in BDNF is implicated in bipolar disorder risk and may have a more significant role in early-onset expression of the disorder.

Indexed as

Bipolar DisorderAdultAge of OnsetAllelesBrain-Derived Neurotrophic FactorFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedOdds RatioPolymorphism, GeneticUnited StatesBDNF protein, humanBrain-Derived Neurotrophic FactorassociationBDNFbipolar disorderbrain-derived neurotrophic factorearly onsetVal66Met

Identifiers

PMID26528762
PMCPMC4672380
OpenAlexW2126505876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.