Evidence map›Paper›PMID 26528484›Full record

ArticleMolecular neuropsychiatry2015

Identification and functional studies of regulatory variants responsible for the association of

Mariela Zeledón, Nicole Eckart, Margaret Taub, Hilary Vernon, Megan Szymanksi, Ruihua Wang, Pei-Lung Chen, Gerry Nestadt, John A McGrath, Akira Sawa and 3 more

Open access · greenAbstract read
In one paragraph

Article in Molecular neuropsychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Transcriptomic identification and developmental mapping ofTurkish journal of biology = Turk biyoloji dergisi · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Neuregulin 3 and its roles in schizophrenia risk and presentation.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Mariela ZeledónMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD ; Predoctoral Training Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD ; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Nicole EckartMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD ; Predoctoral Training Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD.
Margaret TaubBiostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
Hilary VernonMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Megan SzymanksiMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD ; Predoctoral Training Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD.
Ruihua WangMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Pei-Lung ChenDepartment of Medical Genetics, National Taiwan University Hospital, Taipei City, Taiwan.
Gerry NestadtDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
John A McGrathDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD ; Epidemiology-Genetics Program, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
Akira SawaDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Ann E PulverDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD ; Epidemiology-Genetics Program, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
Dimitrios AvramopoulosMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD ; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
David ValleMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Johns Hopkins Medicine · USJohns Hopkins University · USNational Taiwan University Hospital · TW

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI LEEK, JEFFREY T. · 2011 to 2020
$19.9M
Predoctoral Training Program in Human GeneticsT32GM007814 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 1985 to 2021
$10.6M
Research Center for Molecular Pathogenesis of SchizophreniaP20MH084018 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GALLAGHER, MICHAELA · 2008 to 2010
$3.3M
Nuclear pathway of DISC1 in major mental illnesses: biochemistry and cell biologyR01MH069853 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2004 to 2012
$3.2M
Identification of genetic determinants of schizophrenia related phenotypesR01MH085018 · NIMH · JOHNS HOPKINS UNIVERSITY · PI AVRAMOPOULOS, DIMITRIOS · 2010 to 2013
$2.5M
Oxidative stress and schizophrenia: combination of cell biology and brain imagingR01MH092443 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2015
$1.8M
1/2 Schizophrenia Heterogeneity and Toxoplasma ExposureR01MH092515 · NIMH · JOHNS HOPKINS UNIVERSITY · PI AVRAMOPOULOS, DIMITRIOS · 2011 to 2013
$1.0M
Defining of Neurodevelopmental Pathways Regulated by Neuregulin- DISC1 InteractioRC1MH088753 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON, EVA S, SAWA, AKIRA · 2009 to 2010
$933k
PICK1 knockout mice: role for D-serine in neonatal forebrainsR21MH085226 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2010 to 2011
$369k
NHLBI NIH HHS HHSN268200782096CNICHD NIH HHS HHSN275200900011CNIGMS NIH HHS T32 GM007814NIMH NIH HHS P20 MH084018NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH069853NIMH NIH HHS R01 MH085018NIMH NIH HHS R01 MH092443NIMH NIH HHS R01 MH092515NIMH NIH HHS R21 MH085226NIMH NIH HHS RC1 MH088753
6 · The paper itself

Abstract

We previously reported genetic linkage for Schizophrenia (SZ) (NPL of 4.7) at 10q22 in the Ashkenazi Jewish (AJ) population. In follow up fine mapping we found strong evidence of association between three intronic single nucleotide variants (SNVs) in the 5' end of Neuregulin 3 (

Indexed as

Ashkenazidelusionfunctional studiesneuregulin-3NRG3psychiatric disease

Identifiers

PMID26528484
PMCPMC4627703
OpenAlexW2021095126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.