Evidence map›Paper›PMID 26528356›Full record

ArticleArchives of medical science : AMS2015

Lack of association between polymorphisms of the DNA base excision repair genes MUTYH and hOGG1 and keratoconus in a Polish subpopulation.

Ewelina Synowiec, Katarzyna A Wójcik, Anna Czubatka, Piotr Polakowski, Justyna Izdebska, Jerzy Szaflik, Janusz Błasiak, Jacek P Szaflik

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In one paragraph

Article in Archives of medical science : AMS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. MUTYH: Not just polyposis.World journal of clinical oncology · 2020
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ewelina SynowiecDepartment of Molecular Genetics, University of Lodz, Lodz, Poland.
Katarzyna A WójcikDepartment of Molecular Genetics, University of Lodz, Lodz, Poland.
Anna CzubatkaDepartment of Molecular Genetics, University of Lodz, Lodz, Poland.
Piotr PolakowskiDepartment of Ophthalmology, Medical University of Warsaw, SPKSO Ophthalmic University Hospital, Warsaw, Poland.
Justyna IzdebskaDepartment of Ophthalmology, Medical University of Warsaw, SPKSO Ophthalmic University Hospital, Warsaw, Poland.
Jerzy SzaflikDepartment of Ophthalmology, Medical University of Warsaw, SPKSO Ophthalmic University Hospital, Warsaw, Poland.
Janusz BłasiakDepartment of Molecular Genetics, University of Lodz, Lodz, Poland.
Jacek P SzaflikDepartment of Ophthalmology, Medical University of Warsaw, SPKSO Ophthalmic University Hospital, Warsaw, Poland.
Medical University of Warsaw · PLUniversity of Łódź · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionKeratoconus (KC) is a non-inflammatory thinning of the cornea and a leading indication for corneal transplantation. Oxidative stress plays a role in the pathogenesis of this disease. The products of the hOGG1 and MUTYH genes play an important role in the repair of oxidatively modified DNA in the base excision repair pathway. We hypothesized that variability in these genes may change susceptibility to oxidative stress and predispose individuals to the development of KC. We investigated the possible association between the c.977C>G polymorphism of the hOGG1 gene (rs1052133) and the c.972G>C polymorphism of the MUTYH gene (rs3219489) and KC occurrence as well as the modulation of this association by some KC risk factors. MATERIAL AND

methodsA total of 205 patients with KC and 220 controls were included in this study. The polymorphisms were genotyped with polymerase chain reaction (PCR) restriction fragment length polymorphism and PCR-confronting two-pair primer techniques. Differences in genotype and allele frequency distributions were evaluated using the χ(2) test, and KC risk was estimated with an unconditional multiple logistic regression with and without adjustment for co-occurrence of visual impairment, allergies, sex and family history for KC.

resultsWe did not find any association between the genotypes and combined genotypes of the c.977C>G polymorphism of the hOGG1 gene and the c.972G>C polymorphism of the MUTYH gene and the occurrence of KC.

conclusionsOur findings suggest that the c.977C>G-hOGG1 polymorphism and the c.972G>C-MUTYH polymorphism may not be linked with KC occurrence in this Polish subpopulation.

Indexed as

DNA glycosylasesDNA repairgenetic variabilityoxidative DNA damageoxidative stress

Identifiers

PMID26528356
PMCPMC4624754
OpenAlexW2193991874

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.