ArticleArchives of medical science : AMS2015
A retrospective study of antihypertensives in pemphigus: a still unchartered odyssey particularly between thiols, amides and phenols.
Article in Archives of medical science : AMS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- The transition of pemphigus vulgaris into pemphigus foliaceus: A case report.JAAD case reports · 2026Article
- Association of dietary diversity score and severity of pemphigus vulgaris: a cross-sectional study.BMC nutrition · 2025Article
- Evaluation of total sulfhydryl levels and dietary habits in pemphigus vulgaris.Postepy dermatologii i alergologii · 2025Article
- The first description of mucous membrane pemphigoid induced by enalapril maleate: a case report.BMC oral health · 2024Article
- A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic.Frontiers in immunology · 2024Observational
- The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Article
- Treatment-naïve pemphigus patients showing IgG tissue deposits have serum IgG antibodies against desmoglein 1 detected more often than those against desmoglein 3: a monocentre laboratory experience.Postepy dermatologii i alergologii · 2023Article
- Pemphigus: trigger and predisposing factors.Frontiers in medicine · 2023Review
- The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle "exposome" factors.Frontiers in immunology · 2022Review
- Article
- Recurrence of Pemphigus Vulgaris Under Nivolumab Therapy.Frontiers in medicine · 2019Article
- Seborrheic Pemphigus, Antigen Mimicry and the Subsequent-Wrong Diagnostic and Therapeutic Approach?Open access Macedonian journal of medical sciences · 2018Article
- Involvement of Nail Apparatus in Pemphigus Vulgaris in Ethnic Poles Is Infrequent.Frontiers in medicine · 2018Article
- Dew drops on spider web appearance: a newly named pattern of IgG4 deposition in pemphigus with direct immunofluorescence.Postepy dermatologii i alergologii · 2017Review
- Reviewing putative industrial triggering in pemphigus: cluster of pemphigus in the area near the wastewater treatment plant.Postepy dermatologii i alergologii · 2017Review
- Accuracy of molecular diagnostics in pemphigus and bullous pemphigoid: comparison of commercial and modified mosaic indirect immunofluorescence tests as well as enzyme-linked immunosorbent assays.Postepy dermatologii i alergologii · 2017Article
- Uncommon and Unusual Variants of Autoimmune Bullous Diseases.Indian dermatology online journalReview
- Mucosal-dominant pemphigus vulgaris in a captopril-taking woman with angioedema.Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAutoimmune pemphigus diseases comprise several entities with serious prognoses, including the pemphigus vulgaris (PV) group and pemphigus foliaceus (PF) group. Antihypertensives are suspected to be one of the factors triggering/sustaining pemphigus. Here, the data of pemphigus patients regarding arterial hypertension (AH) and taking potentially noxious drugs were statistically analyzed in a setting of a Polish university dermatology department. MATERIAL AND
methodsMedical histories of pemphigus patients (40 admissions of 24 female patients - 13 PV, 11 PF; and 102 admissions of 38 male patients - 24 PV, 14 PF), diagnosed at both immunopathological and biochemical-molecular levels, were studied.
resultsTen of 16 (62.50%) AH-positive PV patients received known PV triggers/sustainers 11 times (1-3 per patient). Fourteen of 15 (93.33%) AH-positive PF patients received known PF triggers/sustainers 21 times (1-3 per patient). No differences in numbers of patients taking potentially culprit drugs were shown between PV and PF (Fisher's exact test: p = 0.0829; Yates' χ(2) test: p = 0.1048). The most frequently used culprit drugs were ramipril in PV and enalapril in PF. On average, each PV/PF AH-positive patient received 3.161 different antihypertensives in his/her history of admissions (2.155 antihypertensives per admission).
conclusionsDrug triggering should be suspected in every case of newly diagnosed or exacerbated pemphigus, as eliminating possible PV/PF triggers/sustainers may alleviate the clinical symptoms and enable the decrease of dose/range of immunosuppressants regardless of pemphigus form. Eliminating possible drug PV/PF triggers/sustainers may alleviate the clinical symptoms and enable the decrease of dose/range of immunosuppressants regardless of pemphigus form.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.