ArticleFrontiers in microbiology2015
VarR controls colonization and virulence in the marine macroalgal pathogen Nautella italica R11.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- Bacterial disease in seaweed aquaculture: pathogen diversity and future solutions.Journal of applied phycology · 2026Review
- A review of quorum-sensing and its role in mediating interkingdom interactions in the ocean.Communications biology · 2025Review
- Genomic and induction evidence for bacteriophage contributions to sargassum-bacteria symbioses.Microbiome · 2024Article
- Pathogen exposure leads to a transcriptional downregulation of core cellular functions that may dampen the immune response in a macroalga.Molecular ecology · 2022Article
- Tight Adherence (Tad) Pilus Genes Indicate Putative Niche Differentiation in Phytoplankton Bloom AssociatedFrontiers in microbiology · 2021Article
- Ecological and Industrial Implications of Dynamic Seaweed-Associated Microbiota Interactions.Marine drugs · 2020Review
- Quorum sensing regulates 'swim-or-stick' lifestyle in the phycosphere.Environmental microbiology · 2020Article
- Exoproteome Analysis of the Seaweed PathogenFrontiers in microbiology · 2017Article
- In Search of Alternative Antibiotic Drugs: Quorum-Quenching Activity in Sponges and their Bacterial Isolates.Frontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing evidence to suggest that macroalgae (seaweeds) are susceptible to infectious disease. However, to date, little is known about the mechanisms that facilitate the colonization and virulence of microbial seaweed pathogens. One well-described example of a seaweed disease is the bleaching of the red alga Delisea pulchra, which can be caused by the bacterium Nautella italica R11, a member of the Roseobacter clade. This pathogen contains a unique luxR-type gene, varR, which we hypothesize controls its colonization and virulence. We show here that a varR knock-out strain is deficient in its ability to cause disease in D. pulchra and is defective in biofilm formation and attachment to a common algal polysaccharide. Moreover complementation of the varR gene in trans can restore these functions to the wild type levels. Proteomic analysis of bacterial cells in planktonic and biofilm growth highlight the potential importance of nitrogen scavenging, mobilization of energy reserves, and stress resistance in the biofilm lifestyle of N. italica R11. Moreover, we show that VarR regulates the expression of a specific subset of biofilm-associated proteins. Taken together these data suggest that VarR controls colonization and persistence of N. italica R11 on the surface of a macroalgal host and that it is an important regulator of virulence.
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