ArticleFrontiers in microbiology2015
Regulation of fucose and 1,2-propanediol utilization by Salmonella enterica serovar Typhimurium.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Harnessing gut microbiota to mitigateVirulence · 2025Review
- Structural properties of short-chain carboxylic acids and alcohols relate to the molecular and physiological response of Salmonella enterica in an acidic environment.Applied microbiology and biotechnology · 2025Article
- Fucosylation of glycoproteins and glycolipids: opposing roles in cholera intoxication.Nature chemical biology · 2025Article
- Investigation of different cold adaptation abilities in Salmonella enterica serotype Typhimurium strains using extracellular metabolomic approach.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- A double ttrA and pduA knock-out mutant of Salmonella Typhimurium is not attenuated for mice (Mus musculus).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Hierarchic regulation of a metabolic pathway: H-NS, CRP, and SsrB controlMicrobiology spectrum · 2024Article
- Gut microbiota carbon and sulfur metabolisms support Salmonella infections.The ISME journal · 2024Article
- Fucosylated glycoproteins and fucosylated glycolipids play opposing roles in cholera intoxication.bioRxiv : the preprint server for biology · 2023Article
- In Silico and In Vitro Investigation of the Distribution and Expression of Key Genes in the Fucose Operon ofMicroorganisms · 2023Article
- Salmonella enterica serovars in absence of ttrA and pduA genes enhance the cell immune response during chick infections.Scientific reports · 2023Article
- Pathogenic and Commensal Gut Bacteria Harboring Glycerol/Diol Dehydratase Metabolize Glycerol and Produce DNA-Reactive Acrolein.Chemical research in toxicology · 2022Article
- Microbial co-occurrence network in the rhizosphere microbiome: its association with physicochemical properties and soybean yield at a regional scale.Journal of microbiology (Seoul, Korea) · 2022Article
- Genomic reconstruction of short-chain fatty acid production by the human gut microbiota.Frontiers in molecular biosciences · 2022Article
- Gut microbiota: a potential target for traditional Chinese medicine intervention in coronary heart disease.Chinese medicine · 2021Review
- A Nitrogen Metabolic Enzyme ProvidesACS infectious diseases · 2021Article
- A diet-specific microbiota drives Salmonella Typhimurium to adapt its in vivo response to plant-derived substrates.Animal microbiome · 2021Article
- The Gut Microbiota of Laying Hens and Its Manipulation with Prebiotics and Probiotics To Enhance Gut Health and Food Safety.Applied and environmental microbiology · 2020Review
- Article
- Std fimbriae-fucose interaction increases Salmonella-induced intestinal inflammation and prolongs colonization.PLoS pathogens · 2019Article
- Metabolic functions of the human gut microbiota: the role of metalloenzymes.Natural product reports · 2019Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After ingestion, Salmonella enterica serovar Typhimurium (S. Typhimurium) encounters a densely populated, competitive environment in the gastrointestinal tract. To escape nutrient limitation caused by the intestinal microbiota, this pathogen has acquired specific metabolic traits to use compounds that are not metabolized by the commensal bacteria. For example, the utilization of 1,2-propanediol (1,2-PD), a product of the fermentation of L-fucose, which is present in foods of herbal origin and is also a terminal sugar of gut mucins. Under anaerobic conditions and in the presence of tetrathionate, 1,2-PD can serve as an energy source for S. Typhimurium. Comprehensive database analysis revealed that the 1,2-PD and fucose utilization operons are present in all S. enterica serovars sequenced thus far. The operon, consisting of 21 genes, is expressed as a single polycistronic mRNA. As demonstrated here, 1,2-PD was formed and further used when S. Typhimurium strain 14028 was grown with L-fucose, and the gene fucA encoding L-fuculose-1-phosphate aldolase was required for this growth. Using promoter fusions, we monitored the expression of the propanediol utilization operon that was induced at very low concentrations of 1,2-PD and was inhibited by the presence of D-glucose.
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