Evidence map›Paper›PMID 26528259›Full record

ReviewFrontiers in microbiology2015

Microbial production of scleroglucan and downstream processing.

Natalia A Castillo, Alejandra L Valdez, Julia I Fariña

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 106 citations in OpenAlex.

  1. Review
  2. Article
  3. Role of Scleroglucan Produced byMolecules (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. High-Efficiency Extraction ofMolecules (Basel, Switzerland) · 2022
    Article
  14. Article
  15. High-Efficiency Production ofFrontiers in microbiology · 2022
    Article
  16. Article
  17. Efficient Production of Scleroglucan byFrontiers in bioengineering and biotechnology · 2021
    Article
  18. Assimilation of Cholesterol byJournal of fungi (Basel, Switzerland) · 2020
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Natalia A CastilloLaboratorio de Biotecnología Fúngica, Planta Piloto de Procesos Industriales Microbiológicos-CONICET San Miguel de Tucumán, Argentina ; Cátedra de Micología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán San Miguel de Tucumán, Argentina.
Alejandra L ValdezLaboratorio de Biotecnología Fúngica, Planta Piloto de Procesos Industriales Microbiológicos-CONICET San Miguel de Tucumán, Argentina ; Cátedra de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán San Miguel de Tucumán, Argentina.
Julia I FariñaLaboratorio de Biotecnología Fúngica, Planta Piloto de Procesos Industriales Microbiológicos-CONICET San Miguel de Tucumán, Argentina ; Cátedra de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Catamarca San Fernando del Valle de Catamarca, Argentina.
National University of Catamarca · ARNational University of Tucumán · ARPlanta Piloto de Procesos Industriales Microbiológicos · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic petroleum-based polymers and natural plant polymers have the disadvantage of restricted sources, in addition to the non-biodegradability of the former ones. In contrast, eco-sustainable microbial polysaccharides, of low-cost and standardized production, represent an alternative to address this situation. With a strong global market, they attracted worldwide attention because of their novel and unique physico-chemical properties as well as varied industrial applications, and many of them are promptly becoming economically competitive. Scleroglucan, a β-1,3-β-1,6-glucan secreted by Sclerotium fungi, exhibits high potential for commercialization and may show different branching frequency, side-chain length, and/or molecular weight depending on the producing strain or culture conditions. Water-solubility, viscosifying ability and wide stability over temperature, pH and salinity make scleroglucan useful for different biotechnological (enhanced oil recovery, food additives, drug delivery, cosmetic and pharmaceutical products, biocompatible materials, etc.), and biomedical (immunoceutical, antitumor, etc.) applications. It can be copiously produced at bioreactor scale under standardized conditions, where a high exopolysaccharide concentration normally governs the process optimization. Operative and nutritional conditions, as well as the incidence of scleroglucan downstream processing will be discussed in this chapter. The relevance of using standardized inocula from selected strains and experiences concerning the intricate scleroglucan scaling-up will be also herein outlined.

Indexed as

bioreactordownstream processingfermentationnon-conventional substratesoptimizationscleroglucan

Identifiers

PMID26528259
PMCPMC4606123
OpenAlexW2185515477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.