Evidence map›Paper›PMID 26528189›Full record

ArticleFrontiers in physiology2015

Effect of oral nitrate supplementation on pulmonary hemodynamics during exercise and time trial performance in normoxia and hypoxia: a randomized controlled trial.

Nicolas Bourdillon, Jui-Lin Fan, Barbara Uva, Hajo Müller, Philippe Meyer, Bengt Kayser

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicolas BourdillonFaculty of Biology and Medicine, Institut des Sciences du Sport de l'Université de Lausanne, University of Lausanne Lausanne, Switzerland ; Department of Physiology, Faculty of Biology and Medicine, University of Lausanne Lausanne, Switzerland.
Jui-Lin FanFaculty of Biology and Medicine, Institut des Sciences du Sport de l'Université de Lausanne, University of Lausanne Lausanne, Switzerland ; Department of Physiology, Faculty of Biology and Medicine, University of Lausanne Lausanne, Switzerland ; Lemanic Neuroscience Doctoral School, University of Lausanne Lausanne, Switzerland.
Barbara UvaFaculty of Biology and Medicine, Institut des Sciences du Sport de l'Université de Lausanne, University of Lausanne Lausanne, Switzerland.
Hajo MüllerCardiology Service, University Hospital of Geneva Geneva, Switzerland.
Philippe MeyerCardiology Service, University Hospital of Geneva Geneva, Switzerland.
Bengt KayserFaculty of Biology and Medicine, Institut des Sciences du Sport de l'Université de Lausanne, University of Lausanne Lausanne, Switzerland ; Department of Physiology, Faculty of Biology and Medicine, University of Lausanne Lausanne, Switzerland.
University of Lausanne · CHUniversity Hospital of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypoxia-induced pulmonary vasoconstriction increases pulmonary arterial pressure (PAP) and may impede right heart function and exercise performance. This study examined the effects of oral nitrate supplementation on right heart function and performance during exercise in normoxia and hypoxia. We tested the hypothesis that nitrate supplementation would attenuate the increase in PAP at rest and during exercise in hypoxia, thereby improving exercise performance.

methodsTwelve trained male cyclists [age: 31 ± 7 year (mean ± SD)] performed 15 km time-trial cycling (TT) and steady-state submaximal cycling (50, 100, and 150 W) in normoxia and hypoxia (11% inspired O2) following 3-day oral supplementation with either placebo or sodium nitrate (0.1 mmol/kg/day). We measured TT time-to-completion, muscle tissue oxygenation during TT and systolic right ventricle to right atrium pressure gradient (RV-RA gradient: index of PAP) during steady state cycling.

resultsDuring steady state exercise, hypoxia elevated RV-RA gradient (p > 0.05), while oral nitrate supplementation did not alter RV-RA gradient (p > 0.05). During 15 km TT, hypoxia lowered muscle tissue oxygenation (p < 0.05). Nitrate supplementation further decreased muscle tissue oxygenation during 15 km TT in hypoxia (p < 0.05). Hypoxia impaired time-to-completion during TT (p < 0.05), while no improvements were observed with nitrate supplementation in normoxia or hypoxia (p > 0.05).

conclusionOur findings indicate that oral nitrate supplementation does not attenuate acute hypoxic pulmonary vasoconstriction nor improve performance during time trial cycling in normoxia and hypoxia.

Indexed as

altitudeexercisehypoxianitrateNOperformance

Identifiers

PMID26528189
PMCPMC4604314
OpenAlexW2163389662

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.