Evidence map›Paper›PMID 26528177›Full record

ArticleFrontiers in aging neuroscience2015

Cognitive training with and without additional physical activity in healthy older adults: cognitive effects, neurobiological mechanisms, and prediction of training success.

Julia Rahe, Jutta Becker, Gereon R Fink, Josef Kessler, Juraj Kukolja, Andreas Rahn, Jan B Rosen, Florian Szabados, Brunhilde Wirth, Elke Kalbe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 8 pooled it
6.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 8 syntheses or guidelines pooled it, 96 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Julia RaheCenter for Neuropsychological Diagnostics and Intervention (CeNDI), Institute of Gerontology, University of Vechta Vechta, Germany ; Department of Neurology, University Hospital Cologne Cologne, Germany.
Jutta BeckerInstitute of Human Genetics, University Hospital Cologne Cologne, Germany.
Gereon R FinkDepartment of Neurology, University Hospital Cologne Cologne, Germany ; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich Jülich, Germany.
Josef KesslerDepartment of Neurology, University Hospital Cologne Cologne, Germany.
Juraj KukoljaDepartment of Neurology, University Hospital Cologne Cologne, Germany ; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich Jülich, Germany.
Andreas RahnDepartment of Geriatrics, St. Franziskus Hospital Lohne Lohne, Germany.
Jan B RosenCenter for Neuropsychological Diagnostics and Intervention (CeNDI), Institute of Gerontology, University of Vechta Vechta, Germany.
Florian SzabadosLaboratory Services Laborarztpraxis Osnabrück Osnabrück, Germany.
Brunhilde WirthInstitute of Human Genetics, University Hospital Cologne Cologne, Germany.
Elke KalbeCenter for Neuropsychological Diagnostics and Intervention (CeNDI), Institute of Gerontology, University of Vechta Vechta, Germany ; Department of Medical Psychology, University Hospital Cologne Cologne, Germany.
University Hospital Cologne · DEUniversity of Vechta · DEForschungszentrum Jülich · DESt. Franziskus Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data is inconsistent concerning the question whether cognitive-physical training (CPT) yields stronger cognitive gains than cognitive training (CT). Effects of additional counseling, neurobiological mechanisms, and predictors have scarcely been studied. Healthy older adults were trained with CT (n = 20), CPT (n = 25), or CPT with counseling (CPT+C; n = 23). Cognition, physical fitness, BDNF, IGF-1, and VEGF were assessed at pre- and post-test. No interaction effects were found except for one effect showing that CPT+C led to stronger gains in verbal fluency than CPT (p = 0.03). However, this superiority could not be assigned to additional physical training gains. Low baseline cognitive performance and BDNF, not carrying apoE4, gains in physical fitness and the moderation of gains in physical fitness × gains in BDNF predicted training success. Although all types of interventions seem successful to enhance cognition, our data do not support the hypotheses that CPT shows superior CT gains compared to CT or that CPT+C adds merit to CPT. However, as CPT leads to additional gains in physical fitness which in turn is known to have positive impact on cognition in the long-term, CPT seems more beneficial. Training success can partly be predicted by neuropsychological, neurobiological, and genetic parameters. Unique Identifier: WHO ICTRP (http://www.who.int/ictrp); ID: DRKS00005194.

Indexed as

combined lifestyle interventionmoderatormotivationneurobiological mechanismspredictor

Identifiers

PMID26528177
PMCPMC4602086
OpenAlexW1949921305

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.