ReviewFrontiers in cellular neuroscience2015
Mechanosensitivity in the enteric nervous system.
Review in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Esophageal peristalsis in health and disease: mechanistic insights.Physiological reviews · 2026Review
- Gut instincts: Multi-level control and neural pathways involved in gastrointestinal interoception.Autonomic neuroscience : basic & clinical · 2026Review
- A Biophysical Model of Human Colonic Motor Pattern Generation in Health and Disease.bioRxiv : the preprint server for biology · 2026Article
- Enteric nervous system in exercise physiology: a microbiota-neural interface.npj metabolic health and disease · 2026Review
- Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis.Nature communications · 2025Article
- Role of voltage-gated CaJournal of neurophysiology · 2025Article
- Article
- Optimization of protocols for immunohistochemical assessment of enteric nervous system in formalin fixed human tissue.bioRxiv : the preprint server for biology · 2024Article
- Tetrodotoxin-resistant mechanosensitivity and L-type calcium channel-mediated spontaneous calcium activity in enteric neurons.Experimental physiology · 2024Article
- CoexpressedMolecular pharmacology · 2024Article
- Association between jejunal remodeling in fasting rats and hypersensitivity of intestinal afferent nerves to mechanical stimulation.Biomechanics and modeling in mechanobiology · 2024Article
- Spatial gene expression profile of Wnt-signaling components in the murine enteric nervous system.Frontiers in immunology · 2024Article
- Calcium image analysis in the moving gut.Neurogastroenterology and motility · 2023Article
- Piezo1 in Digestive System Function and Dysfunction.International journal of molecular sciences · 2023Review
- Dickkopf1 induces enteric neurogenesis and gliogenesis in vitro if apoptosis is evaded.Communications biology · 2023Article
- The enteric nervous system.Physiological reviews · 2023Review
- Intestinal distension orchestrates neuronal activity in the enteric nervous system of adult mice.The Journal of physiology · 2023Article
- Short-Chain Fatty Acids as Bacterial Enterocytes and Therapeutic Target in Diabetes Mellitus Type 2.Biomedicines · 2022Review
- Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract.International journal of molecular sciences · 2022Review
- Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The enteric nervous system (ENS) autonomously controls gut muscle activity. Mechanosensitive enteric neurons (MEN) initiate reflex activity by responding to mechanical deformation of the gastrointestinal wall. MEN throughout the gut primarily respond to compression or stretch rather than to shear force. Some MEN are multimodal as they respond to compression and stretch. Depending on the region up to 60% of the entire ENS population responds to mechanical stress. MEN fire action potentials after mechanical stimulation of processes or soma although they are more sensitive to process deformation. There are at least two populations of MEN based on their sensitivity to different modalities of mechanical stress and on their firing pattern. (1) Rapidly, slowly and ultra-slowly adapting neurons which encode compressive forces. (2) Ultra-slowly adapting stretch-sensitive neurons encoding tensile forces. Rapid adaptation of firing is typically observed after compressive force while slow adaptation or ongoing spike discharge occurs often during tensile stress (stretch). All MEN have some common properties: they receive synaptic input, are low fidelity mechanoreceptors and are multifunctional in that some serve interneuronal others even motor functions. Consequently, MEN possess processes with mechanosensitive as well as efferent functions. This raises the intriguing hypothesis that MEN sense and control muscle activity at the same time as servo-feedback loop. The mechanosensitive channel(s) or receptor(s) expressed by the different MEN populations are unknown. Future concepts have to incorporate compressive and tensile-sensitive MEN into neural circuits that controls muscle activity. They may interact to control various forms of a particular motor pattern or regulate different motor patterns independently from each other.
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