ReviewClujul medical (1957)2015
Safety issues of current analgesics: an update.
Review in Clujul medical (1957), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adverse Health Events Related to Self-Medication Practices Among Elderly: A Systematic Review.Drugs & aging · 2017Pooled it
- Trial
- Optimizing Recovery After Thoracotomy: Evidence-Based Non-Opioid and Multimodal Analgesia - A Narrative Review.Current pain and headache reports · 2026Review
- In Vivo Evaluation of the Analgesic Effects of Orientin With Possible Underlying Mechanisms.Chemistry & biodiversity · 2026Article
- Exploring the antinociceptive activity and toxicological profile of Zn(Valp)The Korean journal of pain · 2025Article
- Assessment of In Vivo Analgesic, Anti-Inflammatory and Wound Healing Properties of Aqueous Leaf Extract ofTheScientificWorldJournal · 2025Article
- ViphyllinJournal of pain research · 2022Article
- Biological Properties ofEvidence-based complementary and alternative medicine : eCAM · 2022Review
- Implementation and outcome of an electronic tool for detection of paracetamol overdose in a tertiary care hospital.International journal of clinical pharmacy · 2021Article
- Is telephone follow-up useful in preventing post-extraction bleeding in patients on antithrombotic treatment?Journal of clinical and experimental dentistry · 2021Article
- Anti-nociceptive effect of Arbutus andrachne L. methanolic leaf extract mediated by CB1, TRPV1 and PPARs in mouse pain models.Inflammopharmacology · 2020Article
- Medical cannabis for chronic pain: can it make a difference in pain management?Journal of anesthesia · 2020Review
- Evaluation of Analgesic and Anti-inflammatory Potential of 80% Methanol Leaf Extract ofJournal of inflammation research · 2020Article
- Cannabinoid system involves in the analgesic effect of protocatechuic acid.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019Article
- Oral Health and Feto-maternal Outcomes in the Context of Sustainable Development Goals.Cureus · 2018Review
- Analgesia (mis)usage on a dental emergency service: a patient survey.Clinical oral investigations · 2018Article
- Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Pattern of Self Prescribed Analgesic Use in a Rural Area of Delhi: Exploring the Potential Role of Internet.Journal of clinical and diagnostic research : JCDR · 2017Article
- Opioid use in patients with rheumatoid arthritis 2005-2014: a population-based comparative study.Clinical rheumatology · 2016Article
- Association between intravenous acetaminophen and reduction in intraoperative opioid consumption during transsphenoidal surgery for pituitary tumors.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain represents a complex experience which can be approached by various medicines. Non-opioid and opioid analgesics are the most common drugs used to manage different types of pain. The increased attention nowadays to pain management entailed concomitantly more frequent adverse drug reactions (ADRs) related to analgesic use. Drug-drug interactions can be sometimes responsible for the adverse effects. However, a significant proportion of analgesic ADRs are preventable, which would avoid patient suffering. In order to draw the attention to analgesics risks and to minimize the negative consequences related to their use, the present review comprises a synthesis of the most important safety issues described in the scientific literature. It highlights the potential risks of the most frequently used analgesic medicines: non-opioid (paracetamol, metamizole, non-steroidal anti-inflammatory drugs) and opioid analgesics. Even if there is a wide experience in their use, they continue to capture attention with safety concerns and with potential risks recently revealed. Acknowledging potential safety problems represents the first step for health professionals in assuring a safe and efficient analgesic treatment with minimum risks to patients. Taking into consideration all medical and environmental factors and carefully monitoring the patients are also essential in preventing and early detecting analgesic ADRs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.