ReviewClujul medical (1957)2013
The management of biofilm formation after hyaluronic acid gel filler injections: a review.
Review in Clujul medical (1957), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation: A Meta-Analysis.Frontiers in surgery · 2021Pooled it
- Recurrent Delayed Inflammatory Reaction After Dermal Filler Injection Treated With Intralesional 5-fluorouracil, Triamcinolone, and Hyaluronidase.Plastic and reconstructive surgery. Global open · 2026Article
- Antimicrobial Activity Versus Virulence Potential of Hyaluronic Acid: Balancing Advantages and Disadvantages.International journal of molecular sciences · 2025Review
- Considerations for Proper Use of Hyaluronidase in the Management of Hyaluronic Acid Fillers.Plastic and reconstructive surgery. Global open · 2025Article
- Development of cream bases suitable for personalized cosmetic products.Medicine and pharmacy reports · 2024Article
- Hyaluronic acid fillers may be longer-lasting than previously described: A case report of delayed filler-associated facial cellulitis.JPRAS open · 2022Article
- Another face of dermal fillers.Postepy dermatologii i alergologii · 2020Review
- Complications after cosmetic periocular filler: prevention and management.Plastic and aesthetic research · 2020Article
- Treatment of Soft Tissue Filler Complications: Expert Consensus Recommendations.Aesthetic plastic surgery · 2018Review
- Skin bacterial flora as a potential risk factor predisposing to late bacterial infection after cross-linked hyaluronic acid gel augmentation.Infection and drug resistance · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimOne of the most popular procedures of facial fillers in recent years has become the use of hyaluronic acid (HA). However, this method may be associated with local side effects of different severity. Many of them are not due to allergies, as previously believed, but to the formation of biofilm. We review the current knowledge on biofilm after HA.
methodsAll pertinent full text papers retrieved from PubMed under search words: "biofilm", "hyaluronic acid", "dermal fillers", "hyaluronic acid complications" and "hyaluronic acid side effects" were analyzed; 29 of 60 articles were selected fro analysis.
resultsLocal infections were reported: 13 cases are attributable to the activation of the biofilm. Clinical evolution is generally mild. Therapy should avoid NSAID and is based on the administration of antibiotics, oral corticosteroids, or 5-Flourouracil. Removal of HA with hyaluronidase has also been proposed.
conclusionsThe use of HA in cosmetic procedures might be accompanied by local adverse effects attributable to biofilm formation. This usually has a mild evolution, but in special cases requires specific therapy.
Indexed as
Identifiers
26527945PMC4462513What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.