ArticleMedical mycology2016
Seroprevalence of histoplasmosis in Kampala, Uganda.
Article in Medical mycology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Systematic Review of Prevalence of Histoplasma Antigenuria in Persons with HIV in Latin America and Africa.Emerging infectious diseases · 2024Pooled it
- Histoplasmosis: a missing piece in the global efforts to end HIV deaths.The lancet. HIV · 2026Review
- Burden and Challenges in the Diagnosis and Treatment of Histoplasmosis Among Persons With Advanced HIV Disease in Uganda, 2025.Open forum infectious diseases · 2026Article
- Assessment of Prior Infection With Histoplasmosis Using Skin Test and Serological Surveys: A Global Systematic Review.Open forum infectious diseases · 2025Review
- Evolving Epidemiology, Improving Diagnostic Tests and Their Importance for the Correct Diagnosis of Histoplasmosis.Journal of fungi (Basel, Switzerland) · 2025Review
- Common virulence factors betweenCurrent research in microbial sciences · 2024Review
- Article
- The seroprevalence of anti-Histoplasma capsulatum IgG antibody among pulmonary tuberculosis patients in seven referral tuberculosis hospitals in Indonesia.PLoS neglected tropical diseases · 2023Article
- Prevalence ofJournal of fungi (Basel, Switzerland) · 2023Article
- Cryptococcal andOpen forum infectious diseases · 2022Article
- Histoplasmosis in Africa: Current perspectives, knowledge gaps, and research priorities.PLoS neglected tropical diseases · 2022Review
- Re-drawing the Maps for Endemic Mycoses.Mycopathologia · 2020Review
- Acute histoplasmosis in travelers: a retrospective study in an Italian referral center for tropical diseases.Pathogens and global health · 2020Article
- HIV-Associated Histoplasmosis: Current Perspectives.HIV/AIDS (Auckland, N.Z.) · 2020Review
- Getting Histoplasmosis on the Map of International Recommendations for Patients with Advanced HIV Disease.Journal of fungi (Basel, Switzerland) · 2019Article
- Histoplasmosis and Tuberculosis Co-Occurrence in People with Advanced HIV.Journal of fungi (Basel, Switzerland) · 2019Review
- Article
- In vitro activity of isavuconazole against fluconazole-resistant isolates of Histoplasma capsulatum.Medical mycology · 2018Article
- Seroprevalence of Histoplasmosis in Somali, Burmese, and Hmong Refugees Residing in Thailand and Kenya.Journal of immigrant and minority health · 2018Article
- Epidemiology of fungal infections in China.Frontiers of medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Histoplasmosis is endemic to the Midwestern United States, but cases have been reported nearly worldwide. A 1970 study found 3.8% skin test sensitivity to Histoplasma capsulatum in Uganda but no systemic study of histoplasmosis exposure has occurred since the onset of the human immunodeficiency virus (HIV) pandemic. This study investigated the seroprevalence of H. capsulatum and sought previously undetected cases of histoplasmosis in Kampala, Uganda. Serum, cerebrospinal fluid (CSF) and/or urine specimens were obtained from HIV-infected persons with suspected meningitis. Specimens were tested for H. capsulatum IgG and IgM by enzyme immune assay and Histoplasma antigen. 147 of the 257 subjects who were enrolled had cryptococcal meningitis. Overall, 1.3% (2/151) of subjects were serum Histoplasma IgG positive, and zero of 151 were IgM positive. Antigen was not detected in any serum (n = 57), urine (n = 37, or CSF (n = 63) samples. Both subjects with serum Histoplasma IgG positivity had cryptococcal meningitis. Histoplasma capsulatum IgG was detected at low levels in persons with HIV/AIDS in Kampala, Uganda. Histoplasmosis is not widespread in Uganda but microfoci do exist. There appears to be no cross-reactivity between Cryptococcus neoformans and Histoplasma antigen testing, and cryptococcosis appears to be at most, a rare cause of positive Histoplasma IgG.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.