ArticleNMR in biomedicine2015
Evaluation of bound and pore water in cortical bone using ultrashort-TE MRI.
Article in NMR in biomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Association Between TJournal of magnetic resonance imaging : JMRI · 2021Trial
- Direct MRI of collagen.eLife · 2026Article
- UTE MRI technical developments and applications in osteoporosis: a review.Frontiers in endocrinology · 2025Review
- Towards assessing and improving the reliability of ultrashort echo time quantitative magnetization transfer (UTE-qMT) MRI of cortical bone: In silico and ex vivo study.Magma (New York, N.Y.) · 2024Article
- Bone Biomarkers Based on Magnetic Resonance Imaging.Seminars in musculoskeletal radiology · 2024Review
- Article
- Comprehensive assessment of osteoporosis in lumbar spine using compositional MR imaging of trabecular bone.European radiology · 2023Article
- Making the invisible visible-ultrashort echo time magnetic resonance imaging: Technical developments and applications.Applied physics reviews · 2022Review
- Ultrashort Echo Time Magnetic Resonance Imaging Techniques: Met and Unmet Needs in Musculoskeletal Imaging.Journal of magnetic resonance imaging : JMRI · 2022Review
- Tissue-Specific TJournal of magnetic resonance imaging : JMRI · 2020Article
- Near infrared spectroscopic assessment of loosely and tightly bound cortical bone water.The Analyst · 2020Article
- Water proton density in human cortical bone obtained from ultrashort echo time (UTE) MRI predicts bone microstructural properties.Magnetic resonance imaging · 2020Article
- Quantitative Ultrashort Echo Time (UTE) Magnetic Resonance Imaging of Bone: An Update.Frontiers in endocrinology · 2020Review
- Article
- Quantitative MRI Musculoskeletal Techniques: An Update.AJR. American journal of roentgenology · 2019Review
- Environmentally-Controlled Near Infrared Spectroscopic Imaging of Bone Water.Scientific reports · 2019Article
- Fast quantitative 3D ultrashort echo time MRI of cortical bone using extended cones sampling.Magnetic resonance in medicine · 2019Article
- Detecting stress injury (fatigue fracture) in fibular cortical bone using quantitative ultrashort echo time-magnetization transfer (UTE-MT): An ex vivo study.NMR in biomedicine · 2018Article
- Measurement of bound and pore water TMagnetic resonance in medicine · 2017Article
- Magnetization transfer imaging of cortical bone in vivo using a zero echo time sequence in mice at 4.7 T: a feasibility study.Magma (New York, N.Y.) · 2016Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Bone water exists in different states with the majority bound to the organic matrix and to mineral, and a smaller fraction in 'free' form in the pores of cortical bone. In this study, we aimed to develop and evaluate ultrashort-TE (UTE) MRI techniques for the assessment of T2*, T1 and concentration of collagen-bound and pore water in cortical bone using a 3-T clinical whole-body scanner. UTE MRI, together with an isotope study using tritiated and distilled water (THO-H2O) exchange, as well as gravimetric analysis, were performed on ten sectioned bovine bone samples. In addition, 32 human cortical bone samples were prepared for comparison between the pore water concentration measured with UTE MRI and the cortical porosity derived from micro-computed tomography (μCT). A short T2* of 0.27 ± 0.03 ms and T1 of 116 ± 6 ms were observed for collagen-bound water in bovine bone. A longer T2* of 1.84 ± 0.52 ms and T1 of 527 ± 28 ms were observed for pore water in bovine bone. UTE MRI measurements showed a pore water concentration of 4.7-5.3% by volume and collagen-bound water concentration of 15.7-17.9% in bovine bone. THO-H2O exchange studies showed a pore water concentration of 5.9 ± 0.6% and collagen-bound water concentration of 18.1 ± 2.1% in bovine bone. Gravimetric analysis showed a pore water concentration of 6.3 ± 0.8% and collagen-bound water concentration of 19.2 ± 3.6% in bovine bone. A mineral water concentration of 9.5 ± 0.6% was derived in bovine bone with the THO-H2O exchange study. UTE-measured pore water concentration is highly correlated (R(2) = 0.72, p < 0.0001) with μCT porosity in the human cortical bone study. Both bovine and human bone studies suggest that UTE sequences could reliably measure collagen-bound and pore water concentration in cortical bone using a clinical scanner.
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