Evidence map›Paper›PMID 26527282›Full record

ArticleSystematic reviews2015

A protocol for a systematic review of the diagnostic accuracy of blood markers, synovial fluid, and tissue testing in periprosthetic joint infections (PJI).

Paul E Beaule, Beverley Shea, Hesham Abedlbary, Nadera Ahmadzai, Becky Skidmore, Ranjeeta Mallick, Brian Hutton, Alexandra C Bunting, Julian Moran, Roxanne Ward and 1 more

Erratum issuedAbstract read
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In one paragraph

Article in Systematic reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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  19. Leukocyte Esterase as a Biomarker in the Diagnosis of Periprosthetic Joint Infection.Medical science monitor : international medical journal of experimental and clinical research · 2017
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Paul E BeauleDivision of Orthopaedic Surgery, University of Ottawa, 501 Smyth Rd., Ottawa, ON, K1H 8L6, Canada. pbeaule@toh.on.ca.
Beverley SheaKnowledge Synthesis Group, Ottawa Hospital Research Institute, Center for Practice-Changing Research, 501 Smyth Rd., Ottawa, ON, K1H 8L6, Canada. bevshea35@gmail.com.
Hesham AbedlbaryDivision of Orthopaedic Surgery, University of Ottawa, 501 Smyth Rd., Ottawa, ON, K1H 8L6, Canada. habdelbary@toh.on.ca.
Nadera AhmadzaiKnowledge Synthesis Group, Ottawa Hospital Research Institute, Center for Practice-Changing Research, 501 Smyth Rd., Ottawa, ON, K1H 8L6, Canada. nahmadzai@ohri.ca.
Becky SkidmoreKnowledge Synthesis Group, Ottawa Hospital Research Institute, Center for Practice-Changing Research, 501 Smyth Rd., Ottawa, ON, K1H 8L6, Canada. bskidmore@rogers.com.
Ranjeeta MallickOttawa Hospital Research Institute, 501 Smyth Rd., Ottawa, ON, K1H 8L6, Canada. rmallick@ohri.ca.
Brian HuttonKnowledge Synthesis Group, Ottawa Hospital Research Institute, Center for Practice-Changing Research, 501 Smyth Rd., Ottawa, ON, K1H 8L6, Canada. bhiddy9999@gmail.com.
Alexandra C BuntingUniversity of Ottawa Faculty of Medicine, 451 Smyth Rd., Ottawa, ON, K1H 8L1, Canada. alexandra.bunting@uottawa.ca.
Julian MoranBruyère Research Institute, 85 Primrose Ave., Ottawa, ON, K1R 6M1, Canada. juliandeanmoran@gmail.com.
Roxanne WardKnowledge Synthesis Group, Ottawa Hospital Research Institute, Center for Practice-Changing Research, 501 Smyth Rd., Ottawa, ON, K1H 8L6, Canada. rward@ohri.ca.
David MoherKnowledge Synthesis Group, Ottawa Hospital Research Institute, Center for Practice-Changing Research, 501 Smyth Rd., Ottawa, ON, K1H 8L6, Canada. dmoher@ohri.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTotal joint replacement (TJR) procedures have been one of the most rewarding interventions for treating patients suffering from joint disease. However, developing a periprosthetic joint infection (PJI) is a serious complication that is associated with the highest burden of cost and reduction in patients' quality of life compared to other complications following TJRs. One of the main challenges facing clinicians who are treating PJIs is accurately diagnosing infection in a timely fashion. Multiple orthopedic associations have published clinical guidelines for diagnosing PJI which are based solely on consensus approaches, expert opinions, and narrative reviews. We believe that a higher quality of scientific rigor is necessary to establish a diagnostic guideline that represents current evidence more accurately and that identifies important knowledge gaps in PJI diagnosis. Therefore, we will conduct a systematic review on diagnostic performance of blood markers, synovial fluids, and tissue tests for diagnosing PJI. METHODS/

designElectronic search strategies will be developed and tested by an experienced medical information specialist in consultation with the review team, and gray literature will be searched using the checklist from CADTH's Grey Matters Light. Two reviewers will independently screen the literature for inclusion using the prespecified eligibility criteria. Non-English language and animal-only studies will be excluded. Quality assessment and data extractions by reviewers will be verified, and disagreements will be resolved through consensus or third party adjudication. We will assess the quality of individual studies using the QUADAS-2 tool and use GRADE to summarize the strength of body of evidence. Analyses of evidence will be conducted in accordance with the Cochrane Handbook for Diagnostic Test Accuracy Reviews. DISCUSSION: We will conduct a systemic review of tests (blood markers, synovial fluids, and tissue testing) for diagnosing PJI in patients' knee, hip, and shoulder joint replacements. This will be the first scientifically rigorous and comprehensive systematic review in the field and may feed into an evidence-based clinical practice guideline. We will compare the findings of this review with the consensus-based guides and discuss the differences, similarities, and knowledge gaps. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015023768.

Indexed as

Blood SedimentationArthroplasty, ReplacementBiomarkersC-Reactive ProteinEarly DiagnosisEvidence-Based MedicineHumansPractice Guidelines as TopicProsthesis-Related InfectionsResearch DesignSynovial FluidSynovial MembraneSystematic Reviews as TopicBiomarkersC-Reactive Protein

Identifiers

PMID26527282
PMCPMC4630899

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.