ArticleInfection and immunity2016
Divergence between the Highly Virulent Zoonotic Pathogen Helicobacter heilmannii and Its Closest Relative, the Low-Virulence "Helicobacter ailurogastricus" sp. nov.
Article in Infection and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Update on the pathogenesis and clinical management ofWorld journal of gastrointestinal pathophysiology · 2025Review
- Characterization of three novelFrontiers in microbiology · 2024Article
- Role of non-World journal of gastroenterology · 2023Review
- Helicobacter ailurogastricus in Patient with Multiple Refractory Gastric Ulcers, Japan.Emerging infectious diseases · 2023Article
- A Tripartite Efflux System Affects Flagellum Stability inInternational journal of molecular sciences · 2022Article
- Methylation-Independent Chemotaxis Systems Are the Norm for Gastric-ColonizingJournal of bacteriology · 2022Article
- Gastric Helicobacter species associated with dogs, cats and pigs: significance for public and animal health.Veterinary research · 2022Review
- Presence ofJournal of personalized medicine · 2022Article
- Differentiation of GastricPathogens (Basel, Switzerland) · 2021Article
- Adhesion ofFrontiers in molecular biosciences · 2021Review
- Antimicrobial Susceptibility Pattern ofMicroorganisms · 2020Article
- Distinct transcriptome signatures of Helicobacter suis and Helicobacter heilmannii strains upon adherence to human gastric epithelial cells.Veterinary research · 2020Article
- In silico proteomic and phylogenetic analysis of the outer membrane protein repertoire of gastric Helicobacter species.Scientific reports · 2018Article
- Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence.The ISME journal · 2018Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter heilmannii naturally colonizes the stomachs of dogs and cats and has been associated with gastric disorders in humans. Nine feline Helicobacter strains, classified as H. heilmannii based on ureAB and 16S rRNA gene sequences, were divided into a highly virulent and a low-virulence group. The genomes of these strains were sequenced to investigate their phylogenetic relationships, to define their gene content and diversity, and to determine if the differences in pathogenicity were associated with the presence or absence of potential virulence genes. The capacities of these helicobacters to bind to the gastric mucosa were investigated as well. Our analyses revealed that the low-virulence strains do not belong to the species H. heilmannii but to a novel, closely related species for which we propose the name Helicobacter ailurogastricus. Several homologs of H. pylori virulence factors, such as IceA1, HrgA, and jhp0562-like glycosyltransferase, are present in H. heilmannii but absent in H. ailurogastricus. Both species contain a VacA-like autotransporter, for which the passenger domain is remarkably larger in H. ailurogastricus than in H. heilmannii. In addition, H. ailurogastricus shows clear differences in binding to the gastric mucosa compared to H. heilmannii. These findings highlight the low-virulence character of this novel Helicobacter species.
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