Evidence map›Paper›PMID 26527148›Full record

ArticleActa crystallographica. Section D, Biological crystallography2015

MeshAndCollect: an automated multi-crystal data-collection workflow for synchrotron macromolecular crystallography beamlines.

Ulrich Zander, Gleb Bourenkov, Alexander N Popov, Daniele de Sanctis, Olof Svensson, Andrew A McCarthy, Ekaterina Round, Valentin Gordeliy, Christoph Mueller-Dieckmann, Gordon A Leonard

Abstract read
In one paragraph

Article in Acta crystallographica. Section D, Biological crystallography, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed.

  1. Journal of applied crystallography · 2026
    Article
  2. Automated workflows for strategy computation and data collection at synchrotron beamlines.Acta crystallographica. Section D, Structural biology · 2026
    Article
  3. Article
  4. Fibril Structure of Desiccation-Protective Tardigrade Protein CAHS-8.Angewandte Chemie (International ed. in English) · 2026
    Article
  5. Article
  6. Article
  7. Enhanced capabilities for multi-crystal data collection based on double mesh scans.Acta crystallographica. Section D, Structural biology · 2025
    Article
  8. Article
  9. Review
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ulrich ZanderStructural Biology Group, European Synchrotron Radiation Facility, CS 40220, 38043 Grenoble, France.
Gleb BourenkovEuropean Molecular Biology Laboratory, Hamburg Outstation, Notkestrasse 85, 22607 Hamburg, Germany.
Alexander N PopovStructural Biology Group, European Synchrotron Radiation Facility, CS 40220, 38043 Grenoble, France.
Daniele de SanctisStructural Biology Group, European Synchrotron Radiation Facility, CS 40220, 38043 Grenoble, France.
Olof SvenssonStructural Biology Group, European Synchrotron Radiation Facility, CS 40220, 38043 Grenoble, France.
Andrew A McCarthyEuropean Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble, France.
Ekaterina RoundUniversité Grenoble Alpes, IBS, 38044 Grenoble, France.
Valentin GordeliyUniversité Grenoble Alpes, IBS, 38044 Grenoble, France.
Christoph Mueller-DieckmannStructural Biology Group, European Synchrotron Radiation Facility, CS 40220, 38043 Grenoble, France.
Gordon A LeonardStructural Biology Group, European Synchrotron Radiation Facility, CS 40220, 38043 Grenoble, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, an automated procedure is described to identify the positions of many cryocooled crystals mounted on the same sample holder, to rapidly predict and rank their relative diffraction strengths and to collect partial X-ray diffraction data sets from as many of the crystals as desired. Subsequent hierarchical cluster analysis then allows the best combination of partial data sets, optimizing the quality of the final data set obtained. The results of applying the method developed to various systems and scenarios including the compilation of a complete data set from tiny crystals of the membrane protein bacteriorhodopsin and the collection of data sets for successful structure determination using the single-wavelength anomalous dispersion technique are also presented.

Indexed as

AnimalsBacillusBacteriorhodopsinsBombyxCluster AnalysisCrystallizationCrystallography, X-RayHalobacterium salinarumInsect ProteinsModels, MolecularMuramidasePlant ProteinsPlantsProteinsSynchrotronsThermolysinBacteriorhodopsinsInsect ProteinsMuramidasePlant ProteinsProteinsthaumatin protein, plantThermolysinhierarchical cluster analysismacromolecular crystallographymulti-crystal data collectionsynchrotron serial crystallography

Identifiers

PMID26527148
PMCPMC4631482

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.