ArticleJournal of exercise nutrition & biochemistry2015
Protective effect of branched chain amino acids on hindlimb suspension-induced muscle atrophy in growing rats.
Article in Journal of exercise nutrition & biochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- An Amino Acid Mixture to Counteract Skeletal Muscle Atrophy: Impact on Mitochondrial Bioenergetics.International journal of molecular sciences · 2024Article
- Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2.Cell reports · 2022Article
- Article
- The Effects of Calcium-Oxidative medicine and cellular longevity · 2020Article
- GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation.Protein & cell · 2018Article
- Exercise preconditioning diminishes skeletal muscle atrophy after hindlimb suspension in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Recent Progress in Space Physiology and Aging.Frontiers in physiology · 2018Review
- PPARγ/Pgc-1α-Fndc5 pathway up-regulation in gastrocnemius and heart muscle of exercised, branched chain amino acid diet fed mice.Nutrition & metabolism · 2018Article
- The Role of Exercise and TFAM in Preventing Skeletal Muscle Atrophy.Journal of cellular physiology · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe effect of BCAA (branched chain amino acid) administration on muscle atrophy during growth phases is not well known. We investigated whether BCAA administration can prevent the muscle atrophy induced by hindlimb suspension in growing male rats.
methodsMale Wistar rats were assigned to 1 of 2 groups (n = 7/group): hindlimb suspension and hindlimb suspension with oral BCAA administration (600 mg·kg(-1)·day(-1), valine 1: leucine 2: isoleucine 1). After 14 days of hindlimb suspension, the weight and mRNA levels of the soleus muscle were measured.
resultsBCAA administration prevented a decrease in soleus muscle weight. BCAA administration attenuated atrogin-1 and MuRF1 mRNA expression, which has been reported to play a pivotal role in muscle atrophy.
conclusionBCAA could serve as an effective supplement for the prevention or treatment of muscle atrophy, especially atrophy caused by weightlessness.
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Registered trials
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