Evidence map›Paper›PMID 26527048›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2015

Cost-Effectiveness of a Physician-Pharmacist Collaboration Intervention to Improve Blood Pressure Control.

Linnea A Polgreen, Jayoung Han, Barry L Carter, Gail P Ardery, Christopher S Coffey, Elizabeth A Chrischilles, Paul A James

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 8 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 8 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Impact of patient care teams on blood pressure control in patients with hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Pooled it
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  6. Impact of integrating pharmacists into primary care teams on health systems indicators: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019
    Pooled it
  7. Guideline
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  9. Trial
  10. A texting-based blood pressure surveillance intervention.Journal of clinical hypertension (Greenwich, Conn.) · 2019
    Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Linnea A PolgreenFrom the Department of Pharmacy Practice and Science, College of Pharmacy (L.A.P., B.L.C., G.P.A.), Department of Family Medicine, College of Medicine (B.L.C., P.A.J.), Departments of Biostatistics (C.S.C.) and Epidemiology (E.A.C.), College of Public Health (E.A.C., C.S.C.), University of Iowa, Iowa City; and Department of Pharmacy Practice, School of Pharmacy, Fairleigh Dickinson University, Madison, NJ (J.H.). linnea-polgreen@uiowa.edu.
Jayoung HanFrom the Department of Pharmacy Practice and Science, College of Pharmacy (L.A.P., B.L.C., G.P.A.), Department of Family Medicine, College of Medicine (B.L.C., P.A.J.), Departments of Biostatistics (C.S.C.) and Epidemiology (E.A.C.), College of Public Health (E.A.C., C.S.C.), University of Iowa, Iowa City; and Department of Pharmacy Practice, School of Pharmacy, Fairleigh Dickinson University, Madison, NJ (J.H.).
Barry L CarterFrom the Department of Pharmacy Practice and Science, College of Pharmacy (L.A.P., B.L.C., G.P.A.), Department of Family Medicine, College of Medicine (B.L.C., P.A.J.), Departments of Biostatistics (C.S.C.) and Epidemiology (E.A.C.), College of Public Health (E.A.C., C.S.C.), University of Iowa, Iowa City; and Department of Pharmacy Practice, School of Pharmacy, Fairleigh Dickinson University, Madison, NJ (J.H.).
Gail P ArderyFrom the Department of Pharmacy Practice and Science, College of Pharmacy (L.A.P., B.L.C., G.P.A.), Department of Family Medicine, College of Medicine (B.L.C., P.A.J.), Departments of Biostatistics (C.S.C.) and Epidemiology (E.A.C.), College of Public Health (E.A.C., C.S.C.), University of Iowa, Iowa City; and Department of Pharmacy Practice, School of Pharmacy, Fairleigh Dickinson University, Madison, NJ (J.H.).
Christopher S CoffeyFrom the Department of Pharmacy Practice and Science, College of Pharmacy (L.A.P., B.L.C., G.P.A.), Department of Family Medicine, College of Medicine (B.L.C., P.A.J.), Departments of Biostatistics (C.S.C.) and Epidemiology (E.A.C.), College of Public Health (E.A.C., C.S.C.), University of Iowa, Iowa City; and Department of Pharmacy Practice, School of Pharmacy, Fairleigh Dickinson University, Madison, NJ (J.H.).
Elizabeth A ChrischillesFrom the Department of Pharmacy Practice and Science, College of Pharmacy (L.A.P., B.L.C., G.P.A.), Department of Family Medicine, College of Medicine (B.L.C., P.A.J.), Departments of Biostatistics (C.S.C.) and Epidemiology (E.A.C.), College of Public Health (E.A.C., C.S.C.), University of Iowa, Iowa City; and Department of Pharmacy Practice, School of Pharmacy, Fairleigh Dickinson University, Madison, NJ (J.H.).
Paul A JamesFrom the Department of Pharmacy Practice and Science, College of Pharmacy (L.A.P., B.L.C., G.P.A.), Department of Family Medicine, College of Medicine (B.L.C., P.A.J.), Departments of Biostatistics (C.S.C.) and Epidemiology (E.A.C.), College of Public Health (E.A.C., C.S.C.), University of Iowa, Iowa City; and Department of Pharmacy Practice, School of Pharmacy, Fairleigh Dickinson University, Madison, NJ (J.H.).
American Association of Colleges of Pharmacy · US

Funding

A collaborative model to improve BP control and minimize racial disparities-CCCR01HL091841 · NHLBI · UNIVERSITY OF IOWA · PI CARTER, BARRY L · 2009 to 2013
$4.7M
A collaborative model to improve BP control and minimize racial disparities--DCCR01HL091843 · NHLBI · UNIVERSITY OF IOWA · PI FOSTER, ERIC D. · 2009 to 2013
$3.6M
Observational data and treatment effectiveness: which methods work best?K25HL122305 · NHLBI · UNIVERSITY OF IOWA · PI POLGREEN, LINNEA ANN · 2015 to 2018
$588k
NHLBI NIH HHS K25 HL122305NHLBI NIH HHS K25HL122305NHLBI NIH HHS R01 HL091841NHLBI NIH HHS R01HL091841NHLBI NIH HHS R01 HL091843NHLBI NIH HHS R01HL091843
6 · The paper itself

Abstract

Previous studies have demonstrated the cost-effectiveness of physician-pharmacist collaborations to improve hypertension control. However, most studies have limited generalizability, lacking minority and low-income populations. The Collaboration Among Pharmacist and Physicians to Improve Blood Pressure Now (CAPTION) trial randomized 625 patients from 32 medical offices in 15 states. Each office had an existing clinical pharmacist on staff. Pharmacists in intervention offices communicated with patients and made recommendations to physicians about changes in therapy. Demographic information, blood pressure (BP), medications, and physician visits were recorded. In addition, pharmacists tracked time spent with each patient. Costs were assigned to medications and pharmacist and physician time. Cost-effectiveness ratios were calculated based on changes in BP measurements and hypertension control rates. Thirty-eight percent of patients were black, 14% were Hispanic, and 49% had annual income <$25 000. At 9 months, average systolic BP was 6.1 mm Hg lower (±3.5), diastolic was 2.9 mm Hg lower (±1.9), and the percentage of patients with controlled hypertension was 43% in the intervention group and 34% in the control group. Total costs for the intervention group were $1462.87 (±132.51) and $1259.94 (±183.30) for the control group, a difference of $202.93. The cost to lower BP by 1 mm Hg was $33.27 for systolic BP and $69.98 for diastolic BP. The cost to increase the rate of hypertension control by 1 percentage point in the study population was $22.55. Our results highlight the cost-effectiveness of a clinical pharmacy intervention for hypertension control in primary care settings.

Indexed as

Interdisciplinary CommunicationPharmacistsPhysiciansAntihypertensive AgentsBlood PressureCooperative BehaviorCost-Benefit AnalysisFemaleHumansHypertensionMaleMiddle AgedOutcome Assessment, Health CareAntihypertensive Agentsblood pressurecost-benefit analysishypertensionpharmaciststherapy

Identifiers

PMID26527048
PMCPMC4644092
OpenAlexW2174938696

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.