ArticleCell reports2015
Murine CMV Infection Induces the Continuous Production of Mucosal Resident T Cells.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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Who cites it
60 citing papers in PubMed.
- Temporal Dissection of TGF-β signaling reveals differential impact during female reproductive mucosal CD8 resident memory T cell differentiation.Mucosal immunology · 2026Article
- Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection.The Journal of experimental medicine · 2025Article
- Tissue-Resident CD8+ T Cells as Mediators of Protective Immunity in Breast Milk Transmission of Human Cytomegalovirus.The Journal of infectious diseases · 2025Article
- Viral infection and antiviral immunity in the oral cavity.Nature reviews. Immunology · 2025Review
- NK cells restrain cytotoxic CD8Science immunology · 2024Article
- Mucosal T-cell responses to chronic viral infections: Implications for vaccine design.Cellular & molecular immunology · 2024Review
- Immune surveillance of cytomegalovirus in tissues.Cellular & molecular immunology · 2024Review
- Virological, innate, and adaptive immune profiles shaped by variation in route and age of host in murine cytomegalovirus infection.Journal of virology · 2024Article
- Late-rising CD4 T cells resolve mouse cytomegalovirus persistent replication in the salivary gland.PLoS pathogens · 2024Article
- Tissue-resident memory T cells in the kidney.Seminars in immunopathology · 2022Review
- Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Tissue-resident memory T cells in the urogenital tract.Nature reviews. Nephrology · 2022Review
- Decoding Tissue-Residency: Programming and Potential of Frontline Memory T Cells.Cold Spring Harbor perspectives in biology · 2021Review
- The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding.Pathogens (Basel, Switzerland) · 2021Article
- Influenza- and MCMV-induced memory CD8 T cells control respiratory vaccinia virus infection despite residence in distinct anatomical niches.Mucosal immunology · 2021Article
- Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Organ-Specific Surveillance and Long-Term Residency Strategies Adapted by Tissue-Resident Memory CD8Frontiers in immunology · 2021Review
- Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8Frontiers in immunology · 2021Article
- Molecular Mechanism of Sphingosine-1-Phosphate Receptor 1 Regulating CD4International journal of general medicine · 2021Article
- Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer.Journal for immunotherapy of cancer · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Cytomegalovirus (CMV) is a herpesvirus that persists for life and maintains extremely large numbers of T cells with select specificities in circulation. However, it is unknown how viral persistence impacts T cell populations in mucosal sites. We found that many murine (M)CMV-specific CD8s in mucosal tissues became resident memory T cells (TRM). These cells adopted an intraepithelial localization in the salivary gland that correlated with, but did not depend on, expression of the integrin CD103. MCMV-specific TRM cells formed early after infection, and spleen-localized cells had reduced capacities to become TRM at late times. Surprisingly, however, small numbers of new TRM cells were formed from the circulating pool throughout infection, favoring populations maintained at high levels in the blood and shifting the immunodominance within the TRM populations over time. These data show that mucosal TRM populations can be dynamically maintained by a persistent infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.