Evidence map›Paper›PMID 26526986›Full record

Trial reportLeukemia2016

Efficacy of ruxolitinib on hepatomegaly in patients with myelofibrosis.

S Verstovsek, E Atallah, J Mascarenhas, H Sun, M Montgomery, V Gupta, R Mesa, J Gotlib

Abstract readClinical Trial, Phase IIILetterRandomized Controlled Trial
In one paragraph

Trial report in Leukemia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Rapid Hepatomegaly From Ruxolitinib Discontinuation Syndrome.HCA healthcare journal of medicine · 2023
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

S VerstovsekDepartment of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.
E AtallahDepartment of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
J MascarenhasTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
H SunIncyte Corporation, Wilmington, DE, USA.
M MontgomeryIncyte Corporation, Wilmington, DE, USA.
V GuptaDepartment of Medicine, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
R MesaDivision of Hematology & Medical Oncology, Mayo Clinic Cancer Center, Scottsdale, AZ, USA.
J GotlibDepartment of Medicine/Division of Hematology, Stanford University School of Medicine/Stanford Cancer Institute, Stanford, CA, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Double-Blind MethodHepatomegalyHumansNitrilesPlacebosPrimary MyelofibrosisPyrazolesPyrimidinesTreatment OutcomeNitrilesPlacebosPyrazolesPyrimidinesruxolitinib

Identifiers

PMID26526986
PMCPMC4895165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.