Evidence map›Paper›PMID 26526846›Full record

ArticleMolecular neurobiology2016

Lentiviral Vector-Mediated p27

Min-Hao Chen, Yong-Hua Liu, Hua Xu, Da-Wei Xu, Cheng-Niu Wang, Yi- Wang, Cheng-Wei Duan, Ying Zhou, Peng Kan, Ai-Guo Shen and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Min-Hao ChenDepartment of Orthopaedics, Affiliated Hospital of Nantong University and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, 20 Xi-Si Road, Nantong, 226001, Jiangsu, People's Republic of China.
Yong-Hua LiuJiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
Hua XuDepartment of Orthopaedics, Affiliated Hospital of Nantong University and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, 20 Xi-Si Road, Nantong, 226001, Jiangsu, People's Republic of China.
Da-Wei XuDepartment of Orthopaedics, The Second Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
Cheng-Niu WangBasic Medical Research Centre, Medical School, Nantong University, Nantong, Jiangsu, 226001, People's Republic of China.
Yi- WangDepartment of Medical Imaging, Medical School, Nantong University, Nantong, Jiangsu, 226001, People's Republic of China.
Cheng-Wei DuanJiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
Ying ZhouJiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
Peng KanDepartment of Orthopaedics, Affiliated Hospital of Nantong University and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, 20 Xi-Si Road, Nantong, 226001, Jiangsu, People's Republic of China.
Ai-Guo ShenJiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
You-Hua WangDepartment of Orthopaedics, Affiliated Hospital of Nantong University and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, 20 Xi-Si Road, Nantong, 226001, Jiangsu, People's Republic of China. wangyouhua_nt@126.com.
Nantong University · CNAffiliated Hospital of Nantong University · CNSecond Affiliated Hospital of Nantong University

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic spinal cord injury (SCI) causes tissue loss and associated neurological dysfunction attributable to both mechanical damage and secondary biochemical and physiological responses. Upregulation of cell cycle proteins occurs in both neurons and glia after SCI and may contribute to these changes. Increased cell cycle protein is associated with neuronal and oligodendroglial apoptosis, reactive astrogliosis, glial scar formation, and microglial activation. Here, using lentiviral vectors (LV), we induced the expression of the cyclin-dependent kinase (CDK) inhibitor p27

Indexed as

Recovery of FunctionAnimalsApoptosisAstrocytesCaspase 3Cell CycleCyclin-Dependent Kinase Inhibitor p27Enzyme ActivationGenetic VectorsInflammation MediatorsLentivirusLocomotionMaleMicrogliaMyelin Basic ProteinRats, Sprague-DawleyCaspase 3Cyclin-Dependent Kinase Inhibitor p27Inflammation MediatorsMyelin Basic ProteinApoptosisCell cyclep27kip1ProliferationSpinal cord injury

Identifiers

PMID26526846
OpenAlexW1910387241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.